|
TIP000 a-TRICHLOROETHYLIDENE GLYCEROL 3330 33
<br />TH
<br />COL
<br />of
<br />ihl-mus TCLo:150 ppm/7H/2Y- INHEAD 21,243,83
<br />1: CAR
<br />ihl-ham TCLo:100 ppm/6H/ ARTODN 43,237,80
<br />77W-I: ETA
<br />orl-mus TD :912 g/kg/78W-I: NCITR* NCI-CG-TR-
<br />CAR 2,76
<br />ihl-mus TC:500 ppm/6H/77W-I: ARTODN 43,237,80
<br />ETA
<br />ihl-mus IC: 150 ppm/7H/2Y-I: INHEAO 21,243,83
<br />CAR
<br />on-man TDLo:2I43 mg/kg:GIT 34ZIAG -,602,69
<br />ihl-hmn TCLo:6900 mg/m3/ AHBAAM 116,131,36
<br />10M:CNS
<br />ihl-hmn TCLo:160 ppm/83M: AIHAAP 23,167,62
<br />CNS
<br />ihl-hmn TDLo:812 mg/kg: BMJOAE 2,689,45
<br />CNS,GIT,LIV
<br />ihl-man TCLo:110 ppm/8H: BJIMAG 28,293,71
<br />EYE,CNS
<br />orl-hmn LDLo:7 g/kg ARTODN 35,295,76
<br />ihl-man LCLo:2900 ppm NZMJAX 50,119,51
<br />oil-rat LC50:3670 mg/kg 28ZPAK -,28,72
<br />ihl-rat LCLo:8000 ppm/4H AIHAAP 30,470,69
<br />orl-mus LD50:2402 mg/kg NTIS** AD-A080-636
<br />ihl-mus LC50:8450 ppm/4H
<br /> APT0A6 9,303,53
<br />ipr-mus LD50:3000 mg/kg EJTXAZ 7,247,74
<br />ivn-mus LD50:34 mg/kg CBCCT* 6,141,54
<br />ipr-dog LD50:1900 mg/kg TXAPA9 10,119,67
<br />scu-dog LDLo:150 mg/kg HBTXAC 5,76,59
<br />ivn-dog LDLo: 150 mg/kg QJPPAL 7,205,34
<br />on-cat LDLo:5864 mg/kg NBTXAC 5,76,59
<br />ihl-cat LCLo:32500 mg/m3/2 H AMBAAM 116,131,36
<br />orl-rbt LDLo:7330 mg/kg HBTXAC 5,76,59
<br />scu-rbt LDLo:I800 mg/kg QJPPAL 7,205,34
<br />ihl-gpg LCLo:37200 ppm/40M
<br /> HBTXAC 5,76,59
<br />IARC Cancer Review: Animal Limited Evidence IMEMDT
<br />20,545,79; Human Inadequate Evidence IMEMDT 20,-
<br />545,79; Animal Sufficient Evidence IMEMDT 11,263,76.
<br />NCI Carcinogenesis Bioassay (gavage); No Evidence: rat
<br />NCITR* NCI-CG-TR-2,76; (gavage); Clear Evidence:
<br />mouse NCITR* NCI-CG-TR-2,76. Community Right To
<br />Know List. Reported in EPA TSCA Inventory. EPA Ge-
<br />netic Toxicology Program.
<br />OSHA PEL: TWA 100 ppm; Cl 1200; Pk 300/5M/2H
<br />ACGIH TLV: TWA 50 ppm; STEL 200 ppm; BEI: trichlo-
<br />roethanol in urine end of shift 320 mg/g creatinine, tri-
<br />chloroethylene in end-exhaled air prior to shift and end
<br />of work week 0.5 ppm
<br />DFG MAK: 50 ppm (260 mg/m3); BAT: blood end of
<br />work week and end of shift 500 p.,g/d1
<br />NIOSH REL: (Trichloroethylene) TWA 250 ppm; (Waste
<br />Anesthetic Gases) CL 2 ppm/lH
<br />DOT Classification: ORM-A; Label: None; Poison B; La-
<br />bel: St. Andrews Cross
<br />THR: Experimental poison by intravenous and subcutane-
<br />ous routes. Moderately toxic experimentally by ingestion
<br />and intraperitoneal routes. Mildly toxic to humans by inges-
<br />tion and inhalation. Mildly toxic experimentally by inhala-
<br />tion. An experimental carcinogen, tumorigen and teratogen.
<br />Human systemic effects by ingestion and inhalation: eye
<br />effects, somnolence, hallucinations or distorted perceptions,
<br />gastrointestinal changes and jaundice. Experimental repro-
<br />ductive effects. Human mutagenic data. An eye and severe
<br />skin irritant. Inhalation of high concentrations causes narco-
<br />sis and anesthesia. A form of addiction has been observed
<br />in exposed workers. Prolonged inhalation of moderate con-
<br />centrations causes headache and drowsiness. Fatalities fol-
<br />lowing severe, acute exposure have been attributed to ven-
<br />tricular fibrillation resulting in cardiac failure. There is
<br />damage to liver and other organs from chronic exposure.
<br />A common air contaminant.
<br />A very dangerous fire hazard when exposed to heat or
<br />flame. Explosive in the form of vapor when exposed to
<br />heat or flame. High concentrations of trichloroethylene va-
<br />por in high-temperature air can be made to burn mildly if
<br />plied with a strong flame. Though such a condition is diffi-
<br />cult to produce, flames or arcs should not be used in closed
<br />equipment which contains any solvent residue or vapor.
<br />Reacts with alkali; epoxides [e.g., 1-chloro-2,3-epoxypro-
<br />pane; 1,4-butanediol mono-2,3-epoxypropylether; 1,4-bu-
<br />tanediol di-2,3-epoxypropylether; 2,2-bis((4(2',3'-epoxy-
<br />propoxy)phenyl)propanel to form the spontaneously
<br />flammable gas dichloroacetylene. Can react violently with
<br />Al; Ba; N204; Li; Mg; liquid 02; 03; KOH: KNO3; Na;
<br />NaOH: Ti. Reacts with water under heat and pressure to
<br />form HC1 gas. When heated to decomposition it emits toxic
<br />fumes of C1. Used as a vapor degreaser and in dry clean-
<br />ing. See also CHLORINATED HYDROCARBONS, ALI-
<br />PHATIC. For further information, see Vol. 3, No. 1 of
<br />DP1M Report.
<br />TIP000 HR: 2
<br />a-TRICHLOROETHYLIDENE GLYCEROL
<br />NIOSH: it 3380000
<br />mf: C5 H 7C1303 mw: 221.47
<br />SYN: a-2-(TRICHLOROMETHYL)- I .3-DIOXOLANE-4-METHANOL
<br />TOXICITY DATA: CODEN:
<br />ipr-mus LD50:920 mg/kg JPETAB 81,72,44
<br />ivn-mus LD50:520 mg/kg JPETAB 81,72,44
<br />THR: Moderately toxic by intraperitoneal and intravenous
<br />routes. When heated to decomposition it emits toxic fumes
<br />of cr.
<br />TIP250 HR: 2
<br />P-TRICHLOROETHYLIDENE GLYCEROL
<br />NIOSH: JI 3440000
<br />mf: C5H7C1303 mw: 221.47
<br />SYN: 3-2-(TRICHLOROMETHYL)- .3-DIOXOLANE-4-METHANOL
<br />TOXICITY DATA: CODEN:
<br />ipr-mus LD50:959 mg/kg JPETAB 81,72,44
<br />ivn-mus LD50:518 mg/kg JPETAB 81,72,44
<br />Ti
<br />TF
<br />C:
<br />ml
<br />P1
<br />Co
<br />S'
<br />Al
<br />Al
<br />El
<br />ES
<br />Fl
<br />Fl
<br />Fl
<br />GI
<br />ii-
<br />ir
<br />il-
<br />iE
<br />rn
<br />St
<br />A
<br />nt
<br />ti
<br />le
<br />t(
<br />4
|