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Test Type: Mutagenicity (mammal cell test): chromosome aberration. <br />Test system: Chinese hamster ovary cells <br />Metabolic activation: with and without metabolic activation <br />Method: OECD Test Guideline 473 <br />Result: positive <br />Test Type: Ames test <br />Test system: Salmonella typhimurium <br />Metabolic activation: with and without metabolic activation <br />Method: OECD Test Guideline 471 <br />Result: positive <br />Test Type: In vivo micronucleus test <br />Species: Mouse <br />Cell type: Bone marrow <br />Application Route: Oral <br />Method: OECD Test Guideline 474 <br />Result: negative <br />Carcinogenicity <br />Limited evidence of carcinogenicity in animal studies <br />Suspected human carcinogens <br />IARC: 2A - Group 2A: Probably carcinogenic to humans (Dichloromethane) <br />NTP: No ingredient of this product present at levels greater than or equal to 0.1% is <br />identified as a known or anticipated carcinogen by NTP. <br />OSHA: No component of this product present at levels greater than or equal to 0.1% is <br />on OSHA's list of regulated carcinogens. <br />Reproductive toxicity <br />No data available <br />Specific target organ toxicity - single exposure <br />Inhalation - May cause drowsiness or dizziness. - Central nervous system <br />Specific target organ toxicity - repeated exposure <br />No data available <br />Aspiration hazard <br />No data available <br />11.2 Additional Information <br />Repeated dose toxicity - Rat - male and female - Oral - 104 Weeks - NOAEL (No observed <br />adverse effect level) - 6 mg/kg <br />Repeated dose toxicity - Rat - male and female - Inhalation - 104 Weeks <br />RTECS: PA8050000 <br />Dizziness, Nausea, Vomiting, narcosis, Cough, irritant effects, Unconsciousness, Shortness <br />of breath, respiratory paralysis, somnolence, depressed respiration, CNS disorders, <br />inebriation <br />Risk of corneal clouding. <br />The following applies to aliphatic halogenated hydrocarbons in general: systemic effect: <br />narcosis, cardiovascular disorders. Toxic effect on liver, kidneys. <br />Dichloromethane is metabolized in the body producing carbon monoxide which increases <br />and sustains carboxyhemoglobin levels in the blood, reducing the oxygen-carrying capacity <br />of the blood. <br />Sigma-Aldrich - 270997 <br />Page 9 of 12 <br />The life science business of Merck KGaA, Darmstadt, Germany <br /> holittiPORQ <br />operates as MilliporeSigma in the US and Canada SiGhia