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ATOXNET PIP - DIURON <br />EXTOXNET <br />Extension Toxicology Network <br />Pesticide Information Profiles <br />hitp://ace.orst.edu/cgi-birL/mis/01/pips/diuron.hini <br />A Pesticide Information Project of Cooperative Extension Offices of Cornell University, Oregon State <br />University, the University of Idaho, and the University of California at Davis and the Institute for <br />Environmental Toxicology. Michigan State University. Major support and funding was provided by the <br />USDA/Extension Service/National Agricultural Pesticide Impact Assessment Program. <br />EXTOXNET primary files maintained and archived at Oregon State University <br />Revised June 1996 <br />Diuron <br />Trade and Other Names: Trade names for products containing diuron include Crisuron, Diater, <br />Di -on, Direx, Karmex, and Unidron. It is often used in combination with other pesticides such as <br />bromacil and hexazinone. <br />Regulatory Status: Diuron is a General Use Pesticide (GUP). The U.S. EPA classifies it as <br />toxicity class III - slightly toxic. However, products containing diuron bear the Signal Word WARNING <br />because it can irritate the eyes and throat. <br />Chemical Class: substituted urea <br />Introduction: Diuron is a substituted urea herbicide used to control a wide variety of annual and <br />perennial broadleaf and grassy weeds, as well as mosses. It is used on non -crop areas and many <br />agricultural crops such as fruit, cotton, sugar cane, alfalfa, and wheat. Diuron works by inhibiting <br />photosynthesis. It may be found in formulations as wettable powders and suspension concentrates. <br />Formulation: It may be found in formulations as wettable powders and suspension concentrates. <br />Toxicological Effects: <br />Acute toxicity: Diuron is slightly toxic to mammals. The oral LD50 in rats is 3400 mg/kg. The <br />dermal LD50 is greater than 2000 mg/kg [4,8]. Some signs of central nervous system depression <br />have been noted at high levels of diuron exposure. For humans, the only reported case of acute, oral <br />exposure to the herbicide produced no significant symptoms or toxicity [4,8,10]. <br />Chronic toxicity: Male rats given extremely high doses of diuron over a 2 -week period showed <br />changes in their spleen and bone marrow. Other chronic effects attributed to moderate to high doses <br />I ora <br />��I2 cul I:--) P.%1 <br />