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EXTOXNET PIP - AMIIRYN EXTOXNET Extension Toxicology Network Pesticide Information Profiles http://ace.orst.edu/cgi-bin/mfs/01 /pips/ametryn.htm A Pesticide Information Project of Cooperative Extension Offices of Cornell University, Oregon State University, the University of Idaho, and the University of California at Davis and the Institute for Environmental Toxicology, Michigan State University. Major support and funding was provided by the USDA/Extension Service/National Agricultural Pesticide Impact Assessment Program. EXTOXNET primary files maintained and archived at Oregon State University Revised 9/95. AMETRYN TRADE OR OTHER NAMES: Product names include Evik, Ametryne, Ametrex, Gesapax (48), G34162, Trinatox-D (a combination with 2,4-D), Crisazina-Crisatrina Kombi (a combination with atrazine)(49), Doruplant, Mebatryne, and Amephyt (50). REGULATORY STATUS: Ametryn is an unrestricted or General Use Pesticide (GUP). In Florida and Texas, ametryn may be applied alone on grapefruit and orange trees. In Florida, it may be applied with simazine for common bermuda grass and annual grasses and broadleaf weeds. In Hawaii, a mixture with diuron may be used on sugarcane (51). INTRODUCTION: Ametryn, a member of the Triazine chemical family, is a herbicide which inhibits photosynthesis and other enzymatic processes. It is used to control broadleaf weeds and annual grasses in pineapple, sugarcane and bananas. It is used on corn and potato crops for general weed control (48). It is also used as a vine desiccant on dry beans and potatoes (50). Ametryn is available as an emulsifiable concentrate, flowable wettable powder and a wettable powder. Products containing ametryn should bear the SIGNAL WORD: CAUTION. The EPA classifies it as Toxicity Class III, slightly toxic (49). TOXICOLOGICAL EFFECTS • Acute Toxicity: Ametryn is slightly toxic to humans. Symptoms of acute exposure to high doses include nausea, vomiting, diarrhea, muscle weakness, and salivation (52). Ametryn is moderately irritating to the eyes, skin, and respiratory tract. The LD50 is the dose of ametryn which is lethal to half of the test animals that ingest it. The oral LD50 of ametryn is 508 mg/kg for rats and 945 mg/kg for mice (42). The LC50 for rats that inhale ametryn for four hours is greater than 2.2 mg/l of air (51). The dermal LD50 is greater than 3,100 mg/kg for rats and 8,160 mg/kg for rabbits (42). Acute eye exposure in rabbits causes a temporary irritation (56). • Chronic Toxicity: No information is currently available • Reproductive Effects: No information is currently available. • Teratogenic Effects: No information is currently available. • Mutagenic Effects: Studies have shown that ametryn is not mutagenic (54). • Carcinogenic Effects: There is not adequate data to determine if ametryn can increase the risk of I of 3 5/12.00 2:22 I'M