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Carcinogenicity May cause cancer. <br />IARC Monographs. Overall Evaluation of Carcinogenicity <br />Benzene (CAS 71-43-2) 1 Carcinogenic to humans. <br />Cumene (CAS 98-82-8) 2B Possibly carcinogenic to humans. <br />Ethylbenzene (CAS 100-41-4) 2B Possibly carcinogenic to humans. <br />Gasoline (CAS 86290-81-5) 2B Possibly carcinogenic to humans. <br />Toluene (CAS 108-88-3) 3 Not classifiable as to carcinogenicity to humans. <br />Xylene (o, m, p isomers) (CAS 1330-20-7) 3 Not classifiable as to carcinogenicity to humans. <br />NTP Report on Carcinogens <br />Benzene (CAS 71-43-2) Known To Be Human Carcinogen. <br />US. OSHA Specifically Regulated Substances (29 CFR 1910.1001-1050) <br />Benzene (CAS 71-43-2) Cancer <br />Reproductive toxicity Suspected of damaging fertility or the unborn child. <br />Benzene, xylene and toluene have demonstrated animal effects of reproductive toxicity. Animal <br />studies of benzene have shown testicular effects, alterations in reproductive cycles, chromosomal <br />aberrations and embryo/fetotoxicity. Ethanol has demonstrated human effects of reproductive <br />toxicity. Can cause adverse reproductive effects - such as birth defects, miscarriages, or infertility. <br />Avoid exposure to women during early pregnancy. Avoid contact during pregnancy/while nursing. <br />Specific target organ toxicity - <br />single exposure <br />May cause drowsiness or dizziness. <br />Specific target organ toxicity - <br />repeated exposure <br />May cause damage to the following organs through prolonged or repeated exposure: Blood. <br />Kidneys. Liver. <br />Aspiration hazard May be fatal if swallowed and enters airways. <br />Chronic effects Repeated exposure of laboratory animals to high concentrations of gasoline vapors has caused <br />kidney damage and cancer in rats and cancer in mice. Gasoline was evaluated for genetic activity <br />in assays using microbial cells, cultured mammalian cells and rat bone marrow cells. The results <br />were all negative so gasoline was considered nonmutagenic under these conditions. <br />Overexposure to this product or its components has been suggested as a cause of liver <br />abnormalities in laboratory animals and humans. Lifetime studies by the American Petroleum <br />Institute have shown that kidney damage and kidney cancer can occur in male rats after prolonged <br />inhalation exposures at elevated concentrations of total gasoline. Kidneys of mice and female rats <br />were unaffected. The U.S. EPA Risk Assessment Forum has concluded that the male rat kidney <br />tumor results are not relevant for humans. Total gasoline exposure also produced liver tumors in <br />female mice only. The implication of these data for humans has not been determined. <br />Further information Symptoms may be delayed. <br />12. Ecological information <br />Ecotoxicity Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. <br />Components Test ResultsSpecies <br />1,2,4, Trimethylbenzene (CAS 95-63-6) <br />Aquatic <br />LC50Fish 7.19 - 8.28 mg/l, 96 hoursFathead minnow (Pimephales promelas) <br />Benzene (CAS 71-43-2) <br />Aquatic <br />EC50Crustacea 8.76 - 15.6 mg/l, 48 hoursWater flea (Daphnia magna) <br />LC50Fish 7.2 - 11.7 mg/l, 96 hoursRainbow trout,donaldson trout <br />(Oncorhynchus mykiss) <br />Cumene (CAS 98-82-8) <br />Aquatic <br />EC50Crustacea 3.55 - 11.29 mg/l, 48 hoursBrine shrimp (Artemia sp.) <br />LC50Fish 2.7 mg/l, 96 hoursRainbow trout,donaldson trout <br />(Oncorhynchus mykiss) <br />Cyclohexane (CAS 110-82-7) <br />Aquatic <br />LC50Fish 3.961 - 5.181 mg/l, 96 hoursFathead minnow (Pimephales promelas) <br />8.3 mg/l, 96 hoursStriped bass (Morone saxatilis) <br />UNLEADED GASOLINE <br />Prepared by 3E Company <br />913457 Version #: 03 Revison date: 23-May-2014 Print date: 23-May-2014 10 / 15