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SECTION 11 : Toxicological information <br /> Acute toxicity <br /> • Oral: LD50 Rat oral 500 mg/kg <br /> • Inhalation: LC50 Rabbit inhalation 295 mg/L/2hr <br /> • Dermal: no data available <br /> Skin corrosion/irritation <br /> no data available <br /> Serious eye damage/irritation <br /> no data available <br /> Respiratory or skin sensitization <br /> no data available <br /> Germ cell mutagenicity <br /> no data available <br /> Carcinogenicity <br /> EPA: Known human carcinogen. IARC: Carcinogenic to humans . NTP: Known to be a human carcinogen <br /> Reproductive toxicity <br /> Several case reports suggest that male sexual performance may be affected by vinyl chloride. However, these studies are limited by lack of quantitative exposure <br /> information and possible co-occurring exposure to other chemicals. Several epidemiological studies have reported an association between vinyl chloride <br /> exposure in pregnant women and an increased incidence of birth defects, while other studies have not reported similar findings. Epidemiological studies have <br /> suggested an association between men occupationally exposed to vinyl chloride and miscarriages in their wives' pregnancies although other studies have not <br /> supported these findings. Testicular damage and decreased male fertility have been reported in rats exposed to low levels for up to 12 months. Animal studies <br />