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Benzene <br />,MSOS-1121 <br />Page 3 <br />.0 <br />SECTION IV. LONG—TERM! ORGANISM THREAT POTENTIAL <br />Carcinogenicity <br />IARC: Limited evidence of carcinogenic effects in animals. Sufficient <br />evidence of carcinogenic effects in humans. <br />NTP/NCI: NTP/NCI has reported carcinogenic effects. <br />SAG has reported carcinogenic effects. <br />SCS: Carcinogenic by RTECS criteria based on cases of leukemia in <br />Fu --mans and rats. Carcinogenic by RTECS criteria in mice. <br />Muta enicity <br />IARC: Not mutagenic in bacteria, yeast, insects, or mouse lymphoma <br />ceTTs. Chromosomal anomalies in humans, rats, and mice were observed. <br />RTECS: Positive mutagenic responses in bacteria, mice, rats, and <br />ranTits were observed. DNA damage and chromosomal breaks in humans <br />were observed. <br />Teratogenicity <br />ARTall abnormalities, cleft palate, and absence of the lower jaw <br />were defects observed in mice. Brain and skeletal defects in rats were <br />observed. Other studies did not show teratogenic effects. <br />RTECS: Abnormalities of the musculoskeletal system and other effects <br />on tFe newborn were observed in:�rats and mice. <br />Reproductive Effects <br />Altera of estrus cycles in rats was observed. Increased <br />testicular :weight and degeneration of the seminiferous tubules in rats, <br />guinea pigs, and rabbits were observed. Fetotoxicity in rats and mice <br />were observed. <br />RTECS: Fetotoxicity, post—implantation mortality, and extra embryonic <br />structures in rats and mice were observed. Pre—implantation mortality, <br />fetal death, and other fetal effects in mice were observed. <br />SECTION V. CHRONIC TOXICITY <br />Appetite ass, -me ignt loss, fatigue, muscle weakness, headaches, <br />dizziness, nervousness, irritability, anemia, irreversible blood changes, <br />and damage to the heart and 1 iver. <br />SECTION VI. PHYSICAL DATA. <br />Molecular weight: 78.12 <br />Boiling Point at 760 mm Hg): 800C (176:F) <br />Me. tlrl oinL at 760 mm H 5.5-C (42°F) <br />Vapor Pressure mm H fat OAC (68`F)1: 74.6 <br />Vapor Density Aires j: 2.77 <br />Specific Gravity water=1): 0.879 <br />Percent Volatile Sy o ume: 100 <br />vaooration Rate(butyl acetate =1): 1 <br />oruoi ity in mater: 5oluole <br />Solvent Solubility: Miscible with alcohol, chloroform, ether, carbon <br />01;uIra e, caroon tetrachloride, glacial acetic acid, acetone, oils. <br />Appearance and Odor: Clear, colorless, flammable liquid with an odor <br />.rresno a or 5 ppm. <br />ENV1RO[OC.�ic BATA <br />