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V�W .W MATERIAL SAFETY DATA SHEET 000002684/F/USA - P-0007.300E Approval Date: 04/03/1998 Print Date: 04/04/1998 Page 9 ------------------------------------------------------- Data for 4-(N-ethyl-N-2-methanesulfonylaminoethyl)-2-methylphenylenediamine sesquisulfate monohydrate Acute Toxicity Data: Oral LD-50 (male rat) : 400 mg/kg (target organ effects: kidney) Oral LD-50 (female rat) : 246 mg/kg N Dermal LD-50: > 1000 mg/kg (highest dose tested) Skin irritation: slight Repeated skin application: moderate irritation Skin sens �ization: moderate Skin sensitization (human) : positive Eye irritation (unwashed eyes) : moderate Eye irritation (washed eyes) : slight Definitions for the following section(s) : LOEL = lowest-observed-effect level, LOAEL = lowest-observed-adverse-effect, NOAEL = no observed-adverse-effect level, NOEL = no-observed-effect level. Carcinogenicity Data: Oral study (2 years, hamster) : NOEL = 0.04 Y. % in diet (highest dose tested) Dermal study (2 years, mouse) : NOEL = 62 mg/kg (only dose tested) ------------------------------------------------------------------------------ 12. ECOLOGICAL INFORMATION Introduction: This environmental effects summary is written to assist in addressing emergencies created by an accidental spill which might occur during the shipment of this material, and, in general, it is not meant to address discharges to sanitary sewers or publically owned treatment works. Summary: Data for the major components of this material have been used to estimate the environmental impact of this material. However, this material, itself, has not been tested for environmental effects. Part A: This material is a moderately alkaline aqueous solution, and this property may cause adverse environmental effects. It is expected to have the following properties: a low biochemical oxygen demand and little potential to cause oxygen depletion in aqueous systems, a low potential to affect aquatic organisms, a low potential to affect secondary waste treatment microbial metabolism, a moderate potential to affect the germine ion and/or early growth of some plants, a low potential to bioconcentrate. Whc iluted with a large amount of water, this material released directly or indirectly into the environment is not expected to have a significant impact.