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MATERIAL SAFETY DATA SHEET Product Name: Base Seal® (Component `A', Isocyanate) MSDS-AO04 Inhalation: This product is a respiratory irritant and potential respiratory sensitizer. Repeated inhalation of vapor or aerosol at levels above the occupational exposure limit could cause respiratory sensitization. Symptoms may include irritation to the eyes, nose, throat, and lungs, possibly combined with dryness of the throat, tightness of chest and difficulty in breathing. The onset of the respiratory symptoms may be delayed for several hours after exposure. A hyper-reactive response to even minimal concentrations of MDI may develop in sensitized persons. Skin Contact: Moderate irritant. Repeated and/or prolonged contact may cause skin sensitization. There is limited evidence from animal studies that skin contact may play a role in respiratory sensitization. These results emphasize the need for protective clothing including gloves to be worn at all times when handling these chemicals or in maintenance work. Eye Contact: The vapour, aerosol, and liquid are irritants. Ingestion: Ingestion may cause irritation of the gastrointestinal tract. Based on the acute oral LD50, this product is considered practically non-toxic by ingestion. Carcinogenic Effects: The ingredients of this product are not classified as carcinogenic by ACGIH or IARC, not regulated as carcinogens by OSHA, and not listed as carcinogens by NTP. Mutagenic Effects: There is no substantial evidence of mutagenic potential. Reproductive Effects: No adverse reproductive effects are anticipated. Teratogenic Effects: No birth defects were seen in two independent (rat) studies. Fetotoxicity was observed at doses that were extremely toxic (including lethal) to the mother. Fetotoxicity was not observed at doses that were not maternally toxic. The doses used in these studies were maximal respirable concentrations well in excess of the defined occupational limits. Remark: A study was conducted where groups of rats were exposed for 6 hours/day, 5 days/week for a lifetime to atmospheres of respirable polymeric MDI aerosol at concentrations of 0. 0.2, 1 or 6 mg/m3. No adverse effects were observed at 0.2 mg/m3. At the 1 mg/m3 concentration, minimal nasal and lung irritant effects were seen. Only at the top concentration (6.0 mg/m3) was there an increased incidence of a benign tumor of the lung (adenoma). One malgnant pulmonary tumor(adenocarcinoma) was seen in the 6.0 mg/m: group. MDI administration to rats in this study did not change the distribution and incidence of tumors from those seen in control animals. The increased incidence of lung tumors is associated with prolonged respiratory irritation and the concurrent accumulation of yellow material in the lung. In the absence of prolonged exposure to high concentrations leading to chronic irritation and lung damage, it is highly unlikely that tumor formation will occur. (MDI). There are reports that chronic exposure to diisocyanates by inhalation may result in permanent decreases in lung function. Page 6 of 9 (A)