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ARCO UNLEADED GASOLINE MSOS NO. APPC VX <br /> Supplemental Exposure to other components of gasoline such as benzene,toluene, xytene. othylbenzens, <br /> Toxicology trimethylbenzene and Whaxane have also been shown to affect reproductive capacity andlor fetal <br /> Information development in laboratory animals. The exact relationship between these affects and humans is not <br /> known. <br /> Exposure to N-nexans, a component of gasoline, has been associated with peripheral neuropathy in <br /> humans. i <br /> ADDITIONAL MTBE TOXICITY INFORMATION: <br /> This material showed a positive response in the mouse lymphoma assay for mutagenesis. Tests m five <br /> other mutagenictly assays were negative. There has been a high incidence of false positives in the MOU58 <br /> ymphoma assay, and this single positive finding does not indicate that MTBE is a potential mutagen <br /> MTBE at very high exposure levels (6000 ppm)did include devok9menial toxxaty in mice,but only at <br /> levels where there was also maternal toxicity- In rabbits exposed to the same MTBE levels, there were no <br /> -:indicators Of any affects on the offspring, even in the presence of maternal toxicity. The abnormal findings <br /> :n the mice (deft palate,etc.)are well-recognized effects of stress in the pregnant mouse and have no <br /> correlation with developmental hazards in humans. <br /> I <br /> Chronic toxicity studies have been completed for MTBE. In these studies,863CF1 mice and F34A rats <br /> were exposed to 400,3000, or 8000 ppm MTBE vapors.6 hrs/day,5 days/waek for ill@. Few adverse <br /> effects were noted for either rats or mice. <br /> Maio and tamale nice exposed to 8000 ppm MTBE vapors developed a slightly higher incidence of benign <br /> liver tumors during their lifetime. No other adverse effects Or increases in tumor incidences were found. <br /> Maio and ton"rats exposed to MTBE vapors developed an increasing incidence of chronic progressive <br /> kidney damage,an effect typically noted in aging rets. These effects were most severe in 3000 and 8000 <br /> ppm exposure groups and were accompanied by an increased incidence of kidney tumors(males only). <br /> These findings are consistent with kidney damage associated with accumulation of protein In cells,an <br /> effect which may be unique to the mate rat Benign testicular tumors were numerically increased in high <br /> doss MTBE male rats,but this is an age-related lesion which typically occurs in a very high proportion of j <br /> control untreated tats. <br /> All of these offects either occur in tissues prone t0 the development of tumors or may occur by a <br /> mechanism not considered relevant to humans. The significance of these findings for human health <br /> hazards estimation Is unclear. <br /> f . 'Regulatory fi#ahnation <br /> SUPERFUND AMENDMENTS AND REAUTHORIZATION ACT OF 1986(SARA),TITLE III <br /> Section 311!312 Hazard Categories; <br /> Delayed(chronic) health hazard <br /> Fite hazard <br /> SECTION 313 <br /> This product contains he following chemicals subject to the reperting requirements established by SARA Tale ill <br /> Component Name <br /> BENZENE <br /> CUMENE <br /> CYCLOHEXANE <br /> ETHYLSENZENE <br /> TOLUENE <br /> XYLENE <br /> TOXIC SUBSTANCES CONTROL ACT(TSCA) <br /> AN compofants Of this product are listed an the TSCA inventory. <br /> COMPREHENSIVE ENVIRONMENTAL RESPONSE,COMPENSATION AND LIABILITY ACT(CERCLA) <br /> This material is covered by CERCLA's PETROLEUM EXEMPTION. <br /> (Rotor to 40 CFR 307.14) <br /> P toats-1I/am <br /> Ps�ed7 <br />