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r;� ���:�-rir�s-�3^-�� �. �� ��� ' r� _*.�����i �-'tv�w i•�w �- _= +� _ �� '��5� :���m ,��'�� � _a <br /> t <br />�� 4'yu �.s #%��"r.�d+?•yc f�kY_�.x�l .�'m� { '"Ar+`�,,�'a'�r.;�7"!'�u�'-� �+^''�. S '��-e ``�?-'��3ptro'�i,L�re;:;: ',�A. `��' "y� � ..�:� :��'- ,,,. �-,;�•y: <br /> response Is stili being Investigated but It is thought,o be an epigenetic prn,ess unique to the female mouse. Inhalation <br /> exposure to whole gasol!ne vapor also caused kidney damage and eventually kldncy cancer In male rats. <br /> No other animal model studied by shown these adverse kidney effccts and there Is no physfologlcal reasr.n to believe that <br /> they would occur In man. The cause of the kidney toxic ty is though! to be due to the Intemcnon of koparafhn <br /> hydrocarl,ons in thc•product with a specific wr`.rm protein,alpha-2-mlcrogiabulin. Male rats synthesis large ixrnoent4 of <br /> this protein which is filtered,reabsorbed,and dcgraded by their kidneys. lsopamfflns or their metabolites combine with <br /> this prulcin and make it"undli citable"by the kidney proteases. Willa repeated exposure,the prutctn-isnparaf m complex <br /> accumulates in the kidney tubules causing significant cell death and regrowth. 11 Is thought that this continuous kidney <br /> Inf try may contribute to the eventual dcveloprrcnt of the tumors. <br /> Tlic data above is obtained from studies sponsored by the P.mcrican Petroleum institute(API), <br /> 12. A'DDMONAL IIFl IM I DATA <br /> ADDITIONAL IJEAL7II DATA CON%JEN7: <br /> This product contains benzene. The OSHA©enzene Standard 129 CFR 1910.10281 contains detailed requirements for <br /> training,exposure monitoring,respiratory protection and.medical surveillanre inggc•a-d by the exposure level. Refer:a <br /> the OSIfA Standard before using this product. Rep;;tcd or prolonged Lrcathing of berucne vapors has been assoclalcd <br /> whth the development ofchromesomal dvnage in cxperimc•ntal antrnals and vaious blood diseases in humans ranging from <br /> aplastle anemia to leukemia(a form of cancer). All of these dise:a_ses can be IaL11. No birth defects have bort shown to <br /> occur in pregnant laboratory animals exposed to doses not toxic to the mother. however,some evidence of fetal toxicity <br /> such as delayed physical development ha,',bccn seen at such levels. The avallable in.--.T.•mdon on the efftv(s o;benzene <br /> on human pregnancies Is Inadequate•but it has been established that bcnr--ene can cross:the human placenta. <br /> This product contains n-hexane. Pm'onged or repeated skin contact or breathing of vapors may cause nerve damage <br /> charnciertzcd by progirssive w akncss and numbness in the arms and legs. Recovery ranges from no recovery to complete <br /> recovery depending upon the seventy of the nerve damage. <br /> 4 <br /> This product contains toluene. Toluene l:as twen reported to decrease immunological responses In test animals, it has <br /> also been reported that when young*rats were exposed to I00n ppm toluene for 14 hours dally,far tun weeks,Irreversible <br /> hearing loss wits detected.The same daily exposure to 700 ppm for as long as 16 weeks was without effect. Sine Clic level <br /> t necessary to produce hearing loss is greater than 7 tinxs the 1987-88 ACGif1 TLV for toluene,worker exposures at or <br /> below 100 ppm is not expected to cause any adverse effect. There are also reports that chronic abusers(glue sniffers, <br /> solvent huffcrs)of solvents containing toluene have sufT rcd Ilver,kia.ary and brain damage. Scientific studfes on toluene <br /> have failed to demonstrate birth defects in rats and mice. However.toluene has been shown to cause delayed growth and <br /> extra ribs in the offspring of rats arrd mice at inhaled doses 1266.399 ppm]that were non-toxic to the mother. Toluene <br /> s has not conclusively been shown to cause adverse rcproduc; •c effects in humans. <br /> This product contains xyler:e.a chcmfcal that has been reported in rauee developmental taxicity in rats and mlcc exposed <br /> by Inhalation during pregnancy. Tyre effects noted consisted of delayed development and minor skeletal vahations; <br /> additionally,when prrgnanl mice were exposed by Ingestion to a level that killed nearly one-third of the test group,lcthahly <br /> tresorptions] and malforn-muQns 1prim.vily cleft palate] occurred. Malformations have not been reported following <br /> inhalation cxposurt. Because of thevcry htglr lcn cls nfcxposure used in these studies,we do not believe that their results <br /> Imply an fncmased risk of trpsoducifve loxicitp to worker.;exposed to xylene levels at or below the exposure standard. <br /> Xylene has given negative results in several miragrrn testtng asauys including the Ames ressai•. In a cancer study <br /> ' sponsored by the National Toxicology Program(,1"1'f¢,teclanira),gradex}•luac gate na evidence of rar.:inogen[efty in rats or <br /> mice dosed dally for two years. <br /> Whole gasoline exhaust was reviewed by the International Agency for Remareh on Cancer(ARCI in their Monograph <br /> VOlumC 46(1989). Evidence for causing cancer was considered inadequate in animals and Inadequate in hunums, IARC <br /> placed this material in Category 28,rmnsidcnng it possibly carcinogenic to humans. <br /> Material Safely Dala Shect-Chevron Regular Casnline page 7 <br /> ire <br /> t;bLy <br />