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<br /> G77IYLFZNZENE ol.n2.10,1 1,14,15,17,18.26,28,
<br /> I'-XYLENE(1.4-DIN1FTHYL I1KNLENK) 01,02.10,1 1.26.2 H.
<br /> '.'.-X1T.ENG 01,02,10.1 1.14.15,17.18.26.28.
<br /> TUIXFNIK 01.02'.10,1 1,14,15,17.18.26.28
<br /> I i EXANE 02.1 o.1 1.1-i,17.2S,
<br /> C YC LO I I F.XA N 1, 0:.02.10,t 1.14,17,26,2ti
<br /> NIL---1SY1.7ERT13U'lYl.E1111:k 01,Iu.11,24.26
<br /> bENZENF 01,02.03A 1,06,10,S i,14,E 7,18,20,28
<br /> 0•XYLENEI1.2-DIMM-lil'L13£N7>:NF) 01,02,10,11,1.1,15.17.18,26,28,
<br /> GASOLINE(GENE R1c) 04,08,14,15,17,18,20,
<br /> REGULATORY LISTS:
<br /> 01�SAUA 313 o2-MASS ICTK 03-N711 Carcinogen
<br /> 04-CA P.vp.65 05.111-10G 06-1,RC Group 1
<br /> 07.lARC Gtuup 2A oH.IANC Group 211 09.SARA 302/304
<br /> l0-PA WK I I-NJ ICIX 12-CERCLA 302.4
<br /> 13-%1N RTK 14=ACG III 7I'J i5-ACCIII STEL
<br /> l0-ACG1I1 Calculated'IFIX 17.OSkIA PIN, 18-OSIIASTEL
<br /> 19-Chcvron TLV 20-EIA Carcinogen 21.TSCA SECT 4
<br /> 22-TSCA SECT 5 SNUB 23.75CA SECT 6 RULE 24-TSCA SECT 12 EXPORT
<br /> 25-75CA SECT 8A CAIR 26-TSCA SECT 81)RFPOlti' 27-75CA SECT 8E
<br /> 28-Canadian).`HMIs
<br /> 11. PROI);1CTTOXICOU-10Y I)A'I',t
<br /> EYE IRRITATION'
<br /> The Dralze Eye trnt;dIon Scan•;range,0-1101 in rabbits is 0.
<br /> SKIN IRRITATION:
<br /> The Draizc Skin frim uy Irritation Score(range,0.8)fora 4-Hour exposure(rabbits)is 0,88. 'This material was not a skin
<br /> sensitizer in the modlAcd Buehler Guinea Pig Sensgwition Tcst.
<br /> DERMAL TOXICITY:
<br /> The dermal LD50 In rabbits Is>5 ml/kg.
<br /> RESPIRATORY/]N I VUATION: NDA
<br /> INGESTION: The oral LD50 in rats ir>5 ml/kg.
<br /> ADDITIONAL TOXICOLOGY DATA:
<br /> Lifet:mc inhalation of whole gasoline vapor has c:auecd imrcasc-d liver tumors In female mice, The mechanism of this
<br /> response Is still being Investigated but it is thought to be an epigenetic process unique to the female mouse. Inhalation
<br /> exposure to whole gasoline vapor also caused kidney damage and eventually kidney cancer In male rats.
<br /> No other ar lural model studied ha+shuwa thew•atb,crse kidney cffevis and there Is no physiological reason to believe that
<br /> they would occur in mart. The cause of aln kidney joxiclty Is Ilwught to lx due to the interaction of Isoparafiin
<br /> hydrocarbons in the product with n specific scrum protein,alpha•2-naieruglubulln. MaJe rats syt)thesls large amounts of
<br /> this protein which Is filtered,reabsorbed,and 41egroded by their kidneys. Isoparallins or their metabolites combine with
<br /> this protein and make It"undigcstable"by the kidney proteases. With repeated exposure,the protein-lsoparaMn complex
<br /> accumulates In the kidney tubules causing significant cell death and regrowth. It is thought that this continuous kidney
<br /> Injury may contribute to the eventual development of the tumors.
<br /> The data above is obtained(ruin studies sponsored by the American Petroleum Institute(API)
<br /> Material Safety Data Sheet•Chevron Unleaded Casaline Page 6
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