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g r <br />'��` �,��t}'7. .Sa� G• 5 I Em g"Kgq <br /> ,..� '-; ��� <br /> SEL OILS <br /> 66-11 <br /> handling operations may sxnerience di'reec dermal contact if <br /> $lacca and clachiag are roc corn. They may <br /> inhalation exposures PCOtereiva <br /> from the flare volatile coanonents� receive small. <br /> 66.3 HUMAN HFgLTH CONSIDF_P,A pYS <br /> 66.3.1 AniniaE Studies <br /> 66.3.1.1 Carcinogenicity <br /> Ganerally, number <br /> even though Ch" 1 and number 2 fuel oils a <br /> industrial y contain aromatic hydrocarbons re not carcinogenic <br /> fuels such as number 6 oil are residual19). 'n contrast. <br /> contain highly condensed aromacie <br /> processes. They may oils which often <br /> be carcinogenicProducts from severe cracking <br /> comi'onencs chick boil above 370• to animals <br /> C (2219), if they contain PAH <br /> Certain currenciv <br /> they are derived available fuel ails may be carc'.nogenic because <br /> with these boiEin from the blendingo <br /> g at higher tem £ fractions boilinz. g belay: 370•C <br /> Fuels which are derived from ca alycic ectocrinSome of <br /> carcinogens (2219), these high-boilins <br /> g Processes may contain <br /> Stud{.es have <br /> potene demonstrated a direct relationship be <br /> y and the concentration of P ween <br /> to form blends. It was h18h-boiling fractions which are added <br /> of 700•F* determined thae v <br /> catalytic gas oil or when floc more [hon 10 volume <br /> PocencY values of the clarified oil is <br /> ,_. borderline significance. blends are Lass Present, the C=or <br /> f7Se tuxaor than 20 and therefore have <br /> of ctte tumor .formation rat Potency value La a <br /> For a value of 20 a in response to a representation <br /> (1818) {see T 500 days would PPlica.tion to mouse skin. <br /> able 66.4), be required for a 501 tumor <br /> petroleum products may Examination of baili.ag ranges of response <br /> carcinogenic not provide an accurate assessment of lender <br /> +sacerials Potential. In the aPinion of gingham as Al.re probably . (2219), these <br /> underestimated carcinogenic and their <br /> or inhibitors. <br /> °r overesti=aced if the diluent con ea insCecocarcinogens <br /> Frazier and Mahlum <br /> Oil blend (FOB) (1819) [estad the initiation activity of a <br /> distillate boiling which contained part of a fuel <br /> L76 and g ae 288.4 and 2,g a heave molecular weight <br /> between 54•C <br /> backs at CD-1 miee8in The FOB (25 mgl vas of a distillate boiling <br /> animals received in a 50 tsL volume. Two weeks aft r initilied to aciorliZPPed <br /> -- acetone twice ceeklysEor of 5 µg Phorbol myrtsca[e acetate <br /> t 1e <br /> acetone. positive 24 veers. Negative caner°Ls were treated In Ovi[h <br /> (R�) or dimechvlb n:anrhraceneois e iniciaced ci[h 50 <br /> iLliciating activity. (DMZA). �'g benzo(a)PyCeze <br /> days. Pproximacely 60 Tile FOS shoved significant <br /> Y Creaser ,A rumors were seen. after <br /> controls, than ,_00 tumors vete observed -li0 <br /> 4 drocreaced FOB was also a in [4e <br /> Hydrocreatmenc has [ sred SAP pasitire <br /> 4 <br /> biologic, <br /> activity been suggested as a Possible method Sar -annex. <br /> t coal derived maceriaZs. I reduei— <br /> n this grauo about L^; <br />