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, .. s, <br /> �' �.� <br /> tNO1 <br /> :e[hr�agiob?�e�yaa loss o <br /> bioodl, rue min ( f =e ozy$ena= e <br /> toxic erfeet Of ritrc-z o r:-rate <br /> u lY 'Y' rocs includes he+r - <br /> pair- and cyanosis_ ° -a==tea, :3usca. `:aAzt:rg, rbest <br /> uirh increasing methew. =z=4ogloain concenons =here <br /> aa- be vcalcacss, dis�iaoss, incoordinam;oa, jai«t paw azd ;oscula; <br /> z-cr,ors (200.4-80)- <br /> 7ariatt; '7-nitroso derivatives ,'ave caused =aii�=art L n,s in <br /> - jarious organ sysze=. 3.r- laborarory ,u�Sls. Generali_., as the <br /> eolecule increases in size, carcinogenic acri-:Pty decreases <br /> =Posure to tbheae coeds should be avoided. Sa2citie 1 orllnri nri <br /> 2 nitroso covpatted, - N-nitrosadisaethylacine <br /> - may be found is Valu=e 1 of the Guide, and h-nit_osadiptrenylaminn <br /> 66.3.5 I�velz az Concern <br /> T-%cre are no cr-iteria or srandards for motel ails. Og�9 <br /> se[ s t:zact-neigh.ed- <br /> average exposure licit (298) has <br /> rcr kerosene az =00 opm. <br /> 66.3.6 Vaz.'.rd Assessment <br /> Fuel oils the= <br /> --elves do nor an ear co be <br /> contain several p czrc_;rogcxts but tbev do <br /> P°lyeyelic aromatic hydroearoons .ilieh are carcinogens <br /> both cellular <br /> inageas (2219). A fuel oil blend vas highly active in <br /> both cellular assays and skin painting studies (1819). in Mutagenic findings were obscured I= as Ames test. 3 manse Positive <br /> assayg a a rat nagat nae a marrow study for fuel oil number 2 (1914), Diesel <br /> aucl <br /> rr��lr: in both the P.aes and =Ouse lymphoma assay <br /> but positive results is cbe rat boas mar_-cw assay (1914), <br /> F <br /> + A rep;udggtive <br /> to 408 tedStudy Virh rats exposed by inhalation at levels up <br /> M su esz no adverse effect; <br /> l _;___ caxie effects of ingested Z:el oils '=eluded alooeciz, <br /> de==al <_ tacion and open sores in the genital arca az e�roased ;a[s. <br /> The oral--- <br /> valL'c3 ranged from 5 to 17.3 g/kg for =ars (1024) <br /> Dermal studies <br /> losis rabbits indicated severe der-�� <br /> s. anox _ <br /> zir t exia. ataxia and ietharz, folloLix s dace�o= S� <br /> (1924). :uek oils g/kg <br /> are also minimally _o <br /> :aooit eves (1-o 24) - No chronic animal data were=oder:,.te1 iouzdY trr,t:ting to <br /> . <br /> Ir, humans, C;75 depression .s tYxs :.iei SvsteLdc reaction to fael <br /> ' ails (17). ingestio <br /> c <br /> and inhaiacian exbd °r less u.-.an ounce ha-s'aee� -atal (17) . ]ermai <br /> r - ..=azrs (1314,1315.1316)es to diesel =ae? ave <br /> :/87 <br />