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4't <br /> INT <br /> a <br /> b6-19 <br /> --UE: . OILS ,=or-bearing <br /> Each <br /> Fag was also <br /> developed a total ac- �tlte hydrotreated <br /> of tha animals a of 2 4 tumors. seudies, mice vete i:titiace4 <br /> a had an av-ra8 In these twice ree,41v for 2G <br /> sous romating a.;civicy acetone. The <br /> tested £ar P 2 veews. cheY "ere Pre ted FOS in <br /> DMSA. �fcac drotr <br /> ..._ rly <br /> :irh 50 N8 solution a= hY for 2 weeks and simila <br /> -jacks with 50 Pl- of a 1:3 witfi acetone hydrotreated FOS p <br /> roup was created The was used as the <br /> control g the hydrotreated FOS. ubxn DMSA Each Mouse had <br /> promoted with activity. with <br /> tumor profloting cupors after 6 months. <br /> measurable were reported in mice treated <br /> initiator. lit; or the mice , tusars <br /> an average of 2.5 c, ors. <br /> treated) skin. <br /> hrdrocruaced FOB on ttonitticiated (acetone- <br /> eni ity ca evaluate the <br /> lutag o£ 3 tesrs <br /> Api has conducted <br /> a battery fur? oil (1914}. <br /> mutagenicity of diesel fuel and "amber 2 stock) gave t. Ca <br /> yumber 2 fuel ail (50t cacalvcically <br /> cracked ud ed co be eouivacai <br /> es assay. it vas j 3 f_EQuencies in <br /> test. ,n ct=e Am h mutant t a <br /> results in each use the reiacivelvacig concentrat`ons. <br /> to acive beta under activation and <br /> rather than ' strain TA9B were observed tae <br /> u 'u it was enic of 12 mi.. <br /> mucag 00 :�g% <br /> ' 1 Phoma assay. vithouc metabolic <br /> mouse ym at a test cancent4ontrol ue-Oawley <br /> non-activation cotsdicicns' Imes the solver"cin study. Sprag <br /> frequcnCy was marrow cy g corn oil by <br /> sucaeion In a rat bone fuel oil dissolved in days. e <br /> activation. number 2 1.25 g/kg/day Ear 5 A high <br /> rats ware administered from 0.125 to from 7.5 ca 12.5$• <br /> a& ranging at alltreatment <br /> gavage at doog aberrar.c cells rangedbreaks +r:s seen significanr <br /> percentage with chromatid were sracisti�ally <br /> percentage of cells <br /> levels. In both cases. the l levels <br /> the Lo'v a' high dose le and mouse <br /> only <br /> ac both the `'`mL'b marrow <br /> negative results in <br /> obcaiped in the ed by <br /> Oiese,l fuel gave were tared undiluted <br /> Positive results gas adminis v far i °r <br /> ly-aphoma assay. The diesel fuel ?.0 or 6.0 mL/k3/da. cite <br /> assay. was 0.6. dose. as well as <br /> cycoge•;te.ic Dose or hi6h" $ignificanc <br /> intraperitoneal inje ettiians ac the mid- s`, istically <br /> Single in} day Pracocot caused <br /> 5 days. tri the 5 G) <br /> high-dose abnormaiicies et91 <br /> increases in <br /> chromosome aducti,7C EgF- eCt5 <br /> and Rehr <br /> , Fmbryocaxieiej •.as '• <br /> Tatar the scud; <br /> ogenieiyKo <br /> 56.1.1.3 oil was Bound. f l oil' <br /> of fuel vas labeled Cull <br /> one teratology Study used 15 0� gestation. <br /> s red by API. the maceriaFrom days 6 through a concentrations <br /> sponsored <br /> were provided. airborn evidence of <br /> rats were aaposad cO here was no and <br /> sip ,Q <br /> 5D)SR daily. rowch <br /> Ire-1111 CA 1"ur0809.4 ppm for 6 hours of Eecal n <br /> 0 S6 or inhibition <br /> of zmoryotoxicity <br /> --- teratogenicity. <br /> development <br /> 6/0J <br /> i <br />