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BENZENE 9705(19-00 Page 4 ci _ <br /> XI. TOXICOLOGICAL DATA ***********************t <br /> ---ACUTE TOXICOLOGY--- <br /> ORAL TOXICITY (RATS) : LD50: 3 . 800 g/kg Moderately toxic <br /> DERMAL TOXICITY (RABBITS) : Slightly toxic <br /> INHALATION TOXICITY (RATS) : LC50: 16000 PPM FOR 4 HRS. Toxic <br /> EYE IRRITATION (RABBITS) : Caused moderate irritation to rabbits. Eye <br /> irritation scores: 18 . 0 at 24 hours , 18 . 0 at 48 hours , 4 . 0 at 72 <br /> 1-• hours, 0 at 7 days. <br /> SKIN IRRITATION (RABBITS) : Moderately irritating to rabbits. <br /> ---GENETIC TOXICOLOGY (SUMMARY) ---- <br /> Benzene was not mutagenic in most mutagenicity test systems, but has <br /> been reported to induce chromosomal changes in bone marrow and <br /> blood cells of some exposed workers. <br /> ---REPRODUCTIVE TOXICOLOGY (SUMMARY) --- <br /> Some animal studies suggest that severe overexposure to benzene may <br /> result in growth retardation to the developing fetus. Some effects <br /> on reproductive organs in mice have also been reported. <br /> ---CHRONIC TOXICOLOGY (SUMMARY) --- <br /> �* Animal studies with benzene by inhalation or by oral administration have <br /> resulted in evidence of carcinogenic effects in a number of tissues <br /> ' and organs, adverse effects on the immune system, chromosomal <br /> changes, anemia and possibly leukemia. Both NTP and IARC list <br /> benzene as a human carcinogen. Long--term exposure to low levels of <br /> benzene (<100 ppm) has been reported to result in blood _ <br /> abnormalities in humans, including anemia and, in rare cases, <br /> w leukemia. These effects may develop over months or years without <br /> warning symptoms. <br /> ****ttttt**tttt****** XII. REGULATORY INFORMATION <br /> GOVERNMENTAL INVENTORY STATUS: All components registered in accordance <br /> with TSCA, EINECS, AICS , and MITI . <br /> DOT: <br /> Shipping Name: Benzene <br /> Hazard Class: Flammable liquid <br /> ID Number: UN 1114 <br /> Railroad STCC: 4908110 <br /> ERG Number: 27 <br /> Comment: RQ for Benzene l0lbs. <br /> v <br /> EEC LABEL CLASS: F T (R45 R11 R48 R23/24/25 S53 S16 S29 S44 ) <br /> US OSHA HAZARD COMMUNICATION STANDARD: Product assessed in accordance <br /> w with OSHA 29 CFR 1910 . 1200 and deter-mined to be hazardous. <br /> RCRA INFORMATION: The disposal of the unused product may be subject tz <br /> RCRA regulations per 40 CFR Part 261 for the reasons including bL: <br /> �. not limited to ignitability, corrosivity, reactivity or fornulaticn <br /> with the contaminants listed in the Toxicity Characteristic (TC) <br /> Rule as determined by the Toxicity Characteristic Leaching Procedure <br /> (TCLP) . Disposal of the used product may be regulated. <br /> BENZENE: 99 . 9616 PCT (TCLP) <br /> FLASH: 12 (--11) F (C) <br /> U.S. Superfund Amendments and Reauthorization Act (SARA) Title III: <br /> This product contains no "EXTREMELY HAZARDOUS SUBSTANCES" . <br /> w <br />