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i <br /> TOLUENE 970566-00 Page 4 Of 6 <br /> *********************** XI. TOXICOLOGICAL DATA ************************ <br /> ---ACUTE TOXICOLOGY---- <br /> ORAL TOXICITY (RATS) : LD50: > 7 g/kg Considered to be no more than <br /> slightly toxic based on single dose level testing at 7 9/kg. <br /> DERMAL TOXICITY (RABBITS) : LD50: > 2 g-/kg Considered to be no more <br /> than slightly toxic based on single dose level testing at 2 G/KG. <br /> INHALATION TOXICITY (RATS) : LC50: 8000 PPM FOR 4 HRS. Practically <br /> nontoxic f <br /> f EYE IRRITATION (RABBITS) : Caused moderate irritation to rabbits. Eye <br /> irritation scores: 12. 0 at 24 hours, 18 . 0 at 48 hours, 18.0 at 72 <br /> hours, 16. 0 at 4 days, 9.0 at 7 days. <br /> SKIN IRRITATION (RABBITS) : Moderately irritating to rabbits. <br /> OTHER ACUTE TOXICITY DATA: Inhalation of vapors/mists may cause <br /> respiratory system irritation. <br /> ---GENETIC TOXICOLOGY (SUMMARY) --- j <br /> { ***Negative Ames Test. ***Mouse Lymphoma (L5178Y/TK+/-) Assay: <br /> Negative. - <br /> --NEUROTOXICOLOGY (SUMMARY) --- f <br /> ****Toluene Inhalation studies (1500 ppm) , 6 hours/day, 5 days/week for <br /> 6 months in rats: No neurotoxicity. fi <br /> --REPRODUCTIVE TOXICOLOGY (SUMMARY) --- <br /> No birth defects were reported when pregnant rats, mice or rabbits were j <br /> exposed to vapors at levels up to 1000 ppm of toluene_ There were <br /> some toxic effects on developing fetuses in other studies including <br /> decreased body weight and survival at 267 ppm or greater. A 2- <br /> generation reproduction study with rats did not result in birth <br /> defects at levels up to 2000 ppm, but there was some growth C <br /> inhibition. The no-effect level (NOEL) for toluene was 500 ppm. <br /> ---CHRONIC TOXICOLOGY (SUMMARY) - <br /> No carcinogenic effects were observed when toluene was applied to the <br /> skin of mice for two years. A 2 year NTP inhalation study at t <br /> levels up to 1200 ppm toluene showed no carcinogenic effects in <br /> r rats or mice. Prolonged or repeated exposure to toluene does not <br /> result in bone marrow injury of blood changes characteristic of <br /> benzene. Prolonged repeated skin contact with low viscosity <br /> materials may defat the skin resulting in possible irritation and <br /> dermatitis . j <br /> ********************* XII . REGULATORY INFORMATION ********************* <br /> GQVERNMENTAL INVENTORY STATUS : All components registered in accordance <br /> with TSCA, EINECS , AILS , MITI and DSL. <br /> DOT: <br /> Shipping Name: Toluene <br /> Hazard Class : Flammable liquid <br /> ID Number: UN 1294 <br /> Railroad STCC: 4909305 <br /> ERG Number: 27 <br /> US OSHA HAZARD COMMUNICATION STANDARD: Product assessed in accordance <br /> with OSHA 29 CFR 1910 . 1200 and determined to be hazardous. <br /> RCRA INFORMATION: The disposal of the unused product may be subject to <br /> RCRA regulations per 40 CFR Part 261 for the reasons including but <br /> not limited to ignitability, corrosivity, reactivity or formulation <br /> with the contaminants listed in the Toxicity Characteristic (TC) <br /> Rule as determined by the Toxicity Characteristic Leaching Procedure <br /> (TCLP) . Disposal of the used product may be regulated. <br /> i <br />