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uEL CIL; <br /> aaadling ogerae:iarss may experience dirac= derma caatac= if prateGri. <br /> gloves and clothing are nor, � rt <br /> or _ Thev rsav also receive singele =� <br /> illation nx�asuras from the more volasrile eoeaaonents. <br /> 66,3 <br /> YAH HAI-rxI COHSIDF;tA'i'IpHS .�. <br /> 66.3.1 Aniaal Studies <br /> 6�•3.1.I Carczrsager�icity ''� <br /> Canerall <br /> y, number L and number 2 fuel oils are not carcinogenic <br /> even crtal they court" aramatie hydrocarbons (2219) - In cancr�xt. <br /> i�uxl Fuck such as number 6 oil ara residual oils vhi <br /> proceia sses, <br /> condensed aromactc products from severe ch ofua <br /> fievv be careinagenic ca animals if they conracrackpAK <br /> COmpenents which boil above 370'C (2219) . <br /> Certain currently availa <br /> COY are derived froble Re <br /> cuel nils may ause <br /> be carcinogenic bec � <br /> m •the blending ,of f=atuous boiling be Lav 370'C <br /> with those boiling at higher temperatures.. Some of these hi <br /> AielS which are derived from calycic cracking gh-boiling <br /> carcinogens (2219) g processes may contain } <br /> Studies have demonstrateda direct _ _ <br /> Potency and the eareceneraticn of high-boiling frac ft ons which are added <br /> to form blenas_ It was <br /> determined � <br /> of 700or" catalytic ss o chAC when not more than 10 voLuma � <br /> potent S it or ciari£ied oil is present. umar r <br /> Y values of the blends the c <br /> are less than 20 and therefore have <br /> borderline significance, The tumor of the tumor potency value is a representation <br /> fariaacicn rate in response to application co mouse skin. <br /> Fora value of 20, 500 dans Vould be required for a 501k cumor response <br /> (1$18) (see Table 66-4) , <br /> pecroieum Ex�lnacion of boiling ranges of blenaed y' <br /> products may mac provide ars accurate assessment of their �. <br /> carcinogenic potential. In the opinion of Bingham ec a <br /> materials are probably g �- (2219) , these ~{ <br /> underes= Ced or carcinagenie and their potency may be <br /> ovcresr- maced if the diluent contains cocarcinogens <br /> or inhibitors. <br /> Frazier and Mahium 1819 <br /> oil blend (FOH) <br /> ,nich contained) tested the initiation accxvit-r of a fue! <br /> distillate boiling at 28$-454• part of a heavy molecular weight <br /> between L76 and 288'C. C and 2,9 parts of a distillate bailing I <br /> backs of CB-t mice The ROH (25 mg) Was applied co the clippca <br /> animals. receLved Ln a 50 tel, volume, Tva weeks after initiation, <br /> doses of 5 ug phorbol myrtstace acetate in 50 she <br /> acetone twice weekly for 2C. veekx, Negative controls were crewted with <br /> acetone. Fes�cive controls were initiaced. vich SQ gg benzo#a#pyrene <br /> (SAP? as• dlmecriyibenzanchracene (pHgA) . 'Rte FOB shoved significant =o <br /> iQit"r-ing activity. Approximately 60 <br /> days_ Creacer than 200 t tumors sere seen after _170 <br /> controls. Ly <br /> were observed in the BAP rasit:Jc �s <br /> F{ydracreared FOR teas also tested in the same msszner. <br /> :ivdrotrea�ent hAs been suggested as ' <br /> b£olagical aCt;city of Coal. ed a-S a tPlsslb in chisod foraoeducing y <br /> - i <br /> 6is7 - �� <br />