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• •r OILS b6.19 I <br /> ::he animals ceveiopea a vocal of- LZ �:s3ors. _ash tumor-bearing + <br /> =Ouse had an average Of Z.4 c=ors- The hydrotreated FOB was also <br /> tasted for promoting acti-:it:. In these scudies, mice were initiated+ <br /> .ir—h 50 AS DKEA. Atter 2. weeks. zhav were promoted =.rice veekiv for 2:► �� <br /> -EElCS with"50 14L of a 1:3 solution of. hydrotreated FOB in acecone- The :__i <br /> concroL groin was created +sick acecone car 2 weeks and similarly <br /> promoted wig cha hydrotreated FOB. The hydrotreated FOB possessed `> <br /> rceasurable tumor promoting activity. When DMSA was used as the <br /> iniciacor- 41i of the mice had tumors after 6 months. Each mouse had <br /> an average of 2.5 tumors. No tumors were reported in mice created with <br /> hvdrocreaced FOR on noniniciaced (ace cone-created) skin. t ! <br /> 66.3.1.2 Hutagenicicy <br /> API has conducted a battary of 3 tests cc evaluate the <br /> enici _J <br /> muck <br /> 3 ry of diesel fual and number 2 fuel oil (1914) , <br /> 77 <br /> `umber 2 fuel oil ( 501 cacalvtically g <br /> cracked stock) -JO=it'.'-.- <br /> results in each rest. .n c:ie manes assay, is was judged eabeeeauivoc:rt <br /> cacner than negative because the relatively high mutant frequencies in <br /> S u strainTA98 were observed ac 4 concentrations. in a <br /> mouse lymphoma assay, , t was mutagenir- under aCCI'atlon and <br /> non-activation conditions. .tet a test concencracion of 1200 mg/mL. cne <br /> 3ucaclon frequency was _' ;,ymts the solvent control vichouc metabolic <br /> activation. In a rat bone marrow cytogenetic study. Sprague-Daulev <br /> rats were administered number 2. fuel oil dissolved in corn oil by <br /> gavage ac dosages ranging from 0125 to 1.25 g/kg/dav for 5 dans. The <br /> percentage of aberrant cells ranged from 7.5 to 12.51 . A high <br /> percentage of cells with chromatid breaks was seen ac all z:reacmenc <br /> levels. In both cases, the increases were statistically significant <br /> only ac the low and high Gose Levels. <br /> i <br /> Diesel fuel gave negative results in bosh the moues and mouse <br /> lvmpnoma assav, ?Oslc1ve results were obtained in the rac bone marrow <br /> r:cogenecic assay. The diesel fuel was admrniscered undilucad by <br /> incrapertconeal injection. Dose was 0.6, 2.0 or 6.0 mL/kg/dav for L or7. "s <br /> days. Single injections ac the mid. or high-dose• as well as the <br /> high-dose .n the 5 dav prococel caused statistically significant <br /> increases in chromosome aonormalit:es k19141 . <br /> 56. 3 . L. 3 Teratogenicit•: , brvoco 1.c:t-s ana Reoroauctive Effects <br /> r <br /> One teratology stuev of fuel oil was found. The study .as <br /> saonsored by e _ The material used was labeled -fuel oil" . No <br /> specifications wweere provided. From days 6 - througn 15 of gescaclon, <br /> rregnanc CRL.COBS CD{SD)BR Vacs were exposes to airborne concencracions <br /> of 0. 86.9 or 408.c. ppm for 5 hours daily. Isere was no evidence o; <br /> ceratogenic iCV, embrvocoxzcicy or inhibition of fecal growth and <br /> development ( 1915) . <br /> 1-7 1 <br /> 6/67 <br /> .c <br />