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iS <br /> 1 — A� <br /> { Ge150I.I1tE � <br /> { 65-25 <br /> I. <br /> liver enzymes, HYpoxemia (low blood oxygen Levels) accomp <br /> aspiration pneumonitis accounts <br /> CUS for the ", S manifestation. ag <br /> # toxicity of the gasoline. Bost s '= direct <br /> hours (2279) . ymptoms are reversible v..-.:iia 4g <br /> Er � <br /> #s <br /> Dermal exposure to gasoline vapor and liquid is also possible. <br /> Considering the physical/chesical properties of the volatile <br /> componants, they should be readily absorbed through the skin (2286). <br /> Uquid gasoline is irritating to the skin. Prolonged contact c i <br /> rchemical burn (2228). Hypersensitivity may develop in ce attain <br /> f� in"VIduals (54) . <br /> Exposure of volunteers to gasoline vapors indicatad no ocular <br /> irritation at <br /> a concentration of 140 <br /> i th <br /> throat was seen at vapor Levels of 270 t0 00 Irritation f s la eyes and <br /> PPm plashed into <br /> [he .:eye, Pain and irritation occurs, but there is only slight, <br /> trausiane corneal epithalial disturbance (19) . <br /> 65.3.2,2 Chronic Toxicologic Effects <br /> i. <br /> 1 'The possible Long-cerin effects of chronic inhalation of gasoline <br /> have: been reported as anorexia, weight loss, weakness and cramps <br /> �_ <br /> The neurological and amaphalopathic effects seen in savers <br /> casae include incoordination and tremors, however, these effects appear <br /> revarsible with therapy and cessation of exposure (1570) . Post•mortes� <br /> findings of gasoline sniffers frequently show cerebral and pulmonary <br /> 4 edana; if death is delayed, necrosis of the liver and kidney ix <br /> evident. The minor components of gasoline such as benzene, xylene and <br /> tatraachyl lead contributa more cn these chronic affects than do chs <br /> " • aliphatic hydrocarbons (2284,2277), <br /> 1"nfrequent or controversial effects of chronic inhalation include <br /> decreased intelligence g and fatal retardation. It is known that <br /> exposura to gasoline vapors Leads to increasad mean blood Lewis <br /> (specific componencs not reported) .in woman and fetuses. la a study <br /> conducted by Hunter SM a_yj. (2282) . a comm=jt7 of 500 Amerfeaa Indians <br /> with pravalenc gasoline abuse showed a high incidance of mental <br /> retardation (46 of live births?. Although alcohol abuse was <br /> widespread, the infants' clinical signs were not typical of fatal i <br /> -. alcohol syndrome. Mathyl marcury poisoning would aceaunt For the <br /> symptoms, however blood and hair mareury Levels within the community <br /> LEI wars low. Therefore this study suggested that the retardation was due i <br /> CO prenatal exposnra to organic lead Presant in the gasoline vapors. <br /> Although there has been a rough correlation between the temporal <br /> increase is gasoline production/consumption, and elevated renal csneer <br /> mortality. geographic ecologic studies comparing counties involved in <br /> petroleum refitting with control counties have shown no si=lficant <br /> 1 � increase in kidney cancer deaths. Cohort studies comparing refinery <br /> workata with the general population; showed no consistent increases in <br /> standardized mortality rates of kidney cancer. However. most of these <br /> studies were not designed or analyzed with a gasoline exposure - kidney <br /> T1 r <br /> ` 1 <br /> 6/87 <br /> _ �� r <br />