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<br /> GEnAraAL`TICAL LAB PAGE 02
<br /> Polydatin Td3s
<br /> fog1 tNFR4y CAT: Pelasamer I92LF as pharmaceutic cad; 118 tarns biphenyls with approx 42%chlor ee). Reviews of envi-
<br /> b - ss cath ort ococ ronmcntal impact and toxicity: L. Fisbbein. Ann. Rev.
<br /> C de- I Pharmacol. 14, 139.156 (1974); R. D Kimbrough. CRC
<br /> real in 7433, Po)y -deft
<br /> -M product
<br /> Reetn. Resrnar. AnExoton. t:ri'L Rev- raX,cQ4 2,443.4911(1974): National Con ranee on
<br /> Sol in i Phenol condensation praduci with polyamines. An ion- P� klor}noted B hsn /a Nov, 19.21, 1975 (EPA-360/6-
<br /> exchaa8r resin speetaUy purified for medicinal use. 73-004. 1976)&67 pp.YAccumulation of airborne PCBs in
<br /> 50.80. foliage: E H. Buckley. Science 216, 320(19112). Arviewf
<br /> ,Iv,tig ON am H. L. Hubbard in Kirk-othmer Eneyc/epedia of Chemical
<br /> nium ;echnolojy vol, S (Interscience, New York. 2nd ed. 1964)
<br /> a the , R (R ) _„,a pp 289-297; O Hutrintu et CL, Tht Chemirry of pCB'r
<br /> de in (CRC 2 ' t 1 ) t I (CRC Press.Cleveland,Olio, 1974)269 pp.J. W. Lloyd at
<br /> rhos. xi a e at..J Orrup Med. 11. 109.113(1916). Review of cartino-
<br /> try of tli p Scenc ity studies. 1AAC Afmw#mpks 18,43.103(1978).
<br /> 1c64.
<br /> or 17 x1 x lc 2 x
<br /> id of i
<br /> $Ur-
<br /> niu8 ! x ><
<br /> 0,1110). —
<br /> "Y as
<br /> ns ■ a x x 1
<br /> �y1- Light amber.granular.f,ec-flowing powder. in”in wit. x - a or Cl
<br /> esh- tar,alcohol,ether,aq solns of acid$and alkalies Under the
<br /> $ted conditions of the oid N N.R. assay for acid-consuming Amckw IJ42.clear, mobile liquid: ev. number CI/mole- J
<br /> oly- capacity,not less than 50 ml 0.1 Nhydrehorie acid is con- cute: 3.10, de 1.381, d1n1 1.392. Distillation range 325-
<br /> luck ruined by 0.2 8 of the resin. 366'. Flash point (open cup) 348.356'F. n 1.627-1.629.
<br /> mol TNF-K^?car. Antacid. Dielectric constant (1000 cyder) 5 6 Q57.4 9(1007
<br /> t Aniclor 1234, fight yellow, viscous liquid; ay. number
<br /> Pon. 7434. Polybasflt. AAg2S.SbISi-si)vcr antimony sulfide. Climolecuic; 4 96 dr 1 495;4111 1.505 Distillation range
<br /> aim 7435. Polybenaarsol. fa•Nydroryphenyitaraonrc and 365.390•. No open cup flash point to boiling. of(1L629-
<br /> pulyarer with jarasal/ehyde;Benzodol. A polymene mixture 1.641. Dielwinc constant(1000 cycles)5 0(25).4. 00-)
<br /> obtained by adding fnrmeidehydc 16M, )10.116 mole)over a LDM orally in weanling rats: 1293 mglka,Kimbrough, los
<br /> 3-hr period to p•hydroxy benzenearsonic acid(0.209 mole)in era
<br /> 180 8 of 9O%HrS4e as 0-5'and keeping it cold for 21 hrs. Arocfor 1160,light yellow, soft. sticky resin: av number
<br /> Dilution of the mixture with H O precipitates the product: C imnlecute: 6 30 d; 1.355;d11J 1 566. Distillation range
<br /> Faith.J.Ain. Chem.Soc 72,93(1950). Description Sones 385-420. No open cup flash point to boiling, q 1 647-
<br /> Of at.,Aniibiw d Chemorher 8,400(I 95S) 1.649. Vitt tnc constant(1000 cycles)4,3(2F); 3.7(!0U).
<br /> White powder Somewhat sd in water; sol in alcoholic LD"orally in weanling rats: 1315 ma/kg. Kimbrough, loc.
<br /> ` NaOH. LDie,.p in mice- 233 mg/kg. No deaths after 4 cit. J
<br /> 1} I!kg 1.8 in mice. Cauilon. Tonic effects in humans include chloracne. pig-
<br /> TtnFRAP CAT: Antiprotozoal. mentation of skin and nalls.excessive eye discharge,aweiling
<br /> of eyelids, distinctive hair follicles, gastrointestinal distur-
<br /> 7436. Polybrofnlnated Blphenyls. PBB$. brominated I banees. In Japan.accidental contamination of rice bran oil
<br /> biphenyls: polybromob;phenyls. Mixtures with stritetures with Kannec)or 400 led to an outbreak of -flat became
<br /> veer similar to polychlorinated biphenyls, q.v..where each X = known as -•Yusho disease", rte M. Kurat$unc of oL. in
<br /> 0,R; H or Br. Once widely used commercially. Preen: H. Hahn EPA-3b0/6-75-00A, loc. cit.,p 14. Toxic symptoms in an;-
<br /> c)- e0,al.Ger,pat 1.161.547(1964 to Chem. Fabnk Kalb),0, mals include heparocellular carcinoma, hypertrophy of the
<br /> of A.Burk,t;.S.psi 3,733,366(1973 to Dow);L.C.Mitchell, liver.adenofibrosis, weight and hair loss,mouth and eyelid 1
<br /> )s. D R. Breckenridge- U.S. pats. 7,763,246 and 3,333,674 edems-acnz!crn lesions.decreased hemoglobin t hemato-
<br /> nd (1973, 1974 both to Ethyl Corp) Persistence in soils: L cnl.8astnc mucosal ulceration and reduced ability to repro-
<br /> at W0,.Jacobs Of al.J.Age Food Chem.24, 1199(1976), Phato• duce. These subsisnon have been listed as carcinogens by
<br /> •o- dellradation L O Ruzo et a1., ibid. 1062. Review of envi• the EPA Second Annual Rtgsr!an (N TF 8t-
<br /> 10 rontr4atal hazards: K..Kay. Environ-Aev.13,74-93(1977); 43. Dec, 1981)pp 206.209.
<br /> R. r F. J. D+Cario Of at., Environ. Health Per:pecr. 23, 371-365 vst in electrical capac:tom o)6ctncal iransformiers,vacu- i
<br /> 0,m (1978) um primps. gartransmiluon turbines. Formerly used in
<br /> .. FlrentaxNr BP-6,major component is J,2'.4,4',5,3'-hexa- US is hydraulic fluids, plasuctrarn. adhesives, fire rCtisr.
<br /> p. b'0—h1/henyl. Soltens at 72', dec above 30ST. Low vapor dints, was extenders.deducting agents. pesticide extenders,
<br /> pews: degraded by uv light. Very sol in bezizxne, toluene; inks, lubricants. cutting oils, in haat transfer systems, car.
<br /> .ly 111401in water. bonleas reproducing pa pe
<br /> sol Nott The 1973 '-Michigan Incident"in which $P-6 was
<br /> ip Menially added to animal feed, and resulted in wide. 7438, Poly'datin. J-Hrdrorr•S.(J-!I•hsdrasvyhenyt)rth-
<br /> ed spread destruction of contaminated farm anims)a.feel to the enyllphenyl.B-D-Bracopynnozi0e; 7-hydroxy-3.(p-hydroxy.
<br /> A tameval of BP-6 from the market. L.J.Caner. Science 192, aryeyl)ihenyl Iflurorl,le: 3.4',5-trihydrozysui bene-3.9-0-
<br /> I- 240(1976). 8lucoslac resveratrol-3•d-mono-D-glucoside: piceld. Cx-
<br /> v• Z.s. us1: Flame retardant. Hugs;mol wt 390.40. C 61.33:,H 3.68%.O 32,79%. twin i.
<br /> from fresh root. of Polygonumne eusprdataSieb. R x Zu ,
<br /> 7437• PolyeAludaMcd Blphenyls• PCBs;chlorinated tvi- Pa1Ygvwacrce, and structure: Nonomurs er a[. yekuaaku j
<br /> Phanyls;chlorgbiphcriyls;Arodor,Clophen;Fenclort Kane- Zauhr83,985(1963),
<br /> r $bloc;Phenoelor;Pyralene;Santotherm. Once widely used
<br /> f. odustnal chemicals
<br /> rtgahigh stability
<br /> contributed to both err
<br /> Ike ar
<br /> commercial usefulness and their long-term deleterious r--{
<br /> environmental aria haalch 07, 33 Early synthesis: H. go pt-ea
<br /> r
<br /> ScMiidt. G. Schulz. Ann. 207, 333 (184!). Commercially
<br /> } available aittCe 1930: C.Penning, Ind Eng- Chem 22, 1180
<br /> (19301, Camrtxrcial PCBs are mixtures. The Aroclors are 0-6-q-caucus$
<br /> eaaractented by four digit numbers. The first two digits
<br /> �dica r that the mixture contains b;phenyis(12),tnphenyls
<br /> s (k) or both (25, 44); the last two digits
<br /> give Percent of chlonnc ,n the mixture fe it Aroc ort,42 cion[ 1.709 hndet ihanol3Ystala. mp 225-226-. (01� -'4 9- fc w `
<br /> 1
<br /> Cottruft rhe crms index 141ore uzing thin section. Par 1091
<br />
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