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Neobor Borax 5 Mol 11Toxicologicalinformation Acute toxicity Other Ingestion: Low acute oral toxicity;LD50 in rats is 3,200 to 3,400 Reproductive/developmental toxicity: Animal feeding studies mg/kg of body weight. in rat,mouse and dog,at high doses,have demonstrated effects Skin/dermal: Low acute dermal toxicity;LD50 in rabbits is on fertility and testes2. Studies with the chemically related boric greater than 2,000 mg/kg of body weight Neobor is poorly acid in the rat,mouse and rabbit,at high doses,demonstrate absorbed through intact skin. developmental effects on the fetus,including fetal weight loss and Inhalation: Low acute inhalation toxicity;LC50 in rats is greater minor skeletal variations3.4. The doses administered were many than 2.0 mg/L(or g/m3). times in excess of those to which humans would normally be Skin irritation: Non-irritant- exposedS. Eye irritation: Draize test in rabbits produced eye irritation Carcinogenicity/mutagenicity: No evidence of carcinogenicity effects. Fifty years of occupational exposure to Neobor indicates in micee. No mutagenic activity was observed for boric acid in a no adverse effects on human eye_Therefore,Neobor is not battery of short-term mutagenicity assays. considered to be a human eye irritant in normal industrial use. Human data: Human epidemiological studies show no increase Sensitization: Neobor is not a skin sensitizer. in pulmonary disease in occupational populations with chronic exposures to boric acid dust and sodium borate dust A recent epidemiology study under the conditions of normal occupational exposure to borate dusts indicated no effect on fertility7. 12 1 Ecologicalinformation Ecotoxicity data Fish toxicity: General: Boron (B) is the element in sodium tetraborate Sea-water9: pentahydrate (Neobos) which is used by convention to report Dab,Liman&Amanda borate product ecological effects.It occurs naturally in sea-water 96-hr LC50=74 mg B/Lt at an average concentration of 5 mg B/L and generally occurs in Fresh waterla fresh water at concentrations up to 1 mg B/L In dilute aqueous Rainbow trout,S.gairdneri(embryo4arval stage) solutions the predominant boron species present is 24-day LC50=88 mg B/Lf undissociated boric acid. To convert sodium tetraborate 32-day LCS0=54 mg B/Lf pentahydrate into the equivalent boron (B) content,multiply by Goldfish, Carazius aumtus(embryo-larval stage) 0.1484. 7-day LC50=65 mg B/Lf Phytotoxicity: Boron is an essential micronutrient for healthy 3-day LC50=71 mg B/Lf growth of plants;however,it can be harmful to boron sensitive plants in high quantities. Care should be taken to minimize the Environmental fate data amount of Neobor released to the environment Persistence/degradation: Boron is naturally occurring and Algal toxicity: ubiquitous in the environment Neobor decomposes in the Green algae,Scenedamus subspicatus environment to natural borate. 96-hr EC 10=24 mg B/Lt Octanol/water partition coefficient: No value. In aqueous Invertebrate toxicity$ solution sodium tctraborate pentahydrate is converted Daphnids,Daphnia magna straws substantially into undissociated boric acid. 24-hr EC50=242 mg B/Lt Soil mobility:Neoboris soluble in water and is leachable through normal soil- Test substance: f sodium tetraborate 13 considerations Disposal guidance: Small quantities of Neobor can usually be RCRA(40 CFR 261): Neoboris not listed under any sections of disposed of at landfill sites. No special disposal treatment is the Federal Resource Conservation and Recovery Act(RCRA). required,but local authorities should be consulted about any NPRI(Canada): Neobor is not listed on the Canadian National specific local requirements. Tonnage quantities of product Pollutant Release Inventory. should,if possible,be used for an appropriate application. Refer to Section 15 for additional regulatory information. 14 , •• • DOT hazardous classification: Sodium tetraborate TDG Canadian transportation: Sodium tetraborate pentahydrate (Neobo,-) is not regulated by the U.S.Department pentahydrate (Neobos) is not regulated under Transportation of of Transportation(DOT) and is therefore not considered a Dangerous Goods (I'DG). hazardous material/substance. International transportation: Sodium tetraborate pentahydrate (Neobor) has no UN Number,and is not regulated under international rail,road,water or air transport regulations. 01996 U.S.Borax Inc. US-US-NE 3 of 4