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Product Name : Gasoline with Ethanol page 1.2 of 15 i <br /> Product Code - Multiple <br /> Muta.genxcity- Excessive consumption of alcoholic beverages has been <br /> associated with chromosomal aberrations in white blood cells . <br /> Depending on the animal species being tested, ethanol may <br /> produce chromosomal damage, DNA damage and mutation in both <br /> somatic and germ cells <br /> Toluene (CAS# 108-88-3) <br /> Target Organ (s) : Epidemiology studies suggest that chronic <br /> occupational overexposure to toluene may damage color vision_ <br /> Subchronic and chronic inhalation studies with toluene produced <br /> kidney and liver damage, hearing loss and central nervous system <br /> (brain) damage in laboratory animals . Intentional misuse by <br /> deliberate inhalation of high concentrations of toluene has been <br /> shown to cause liver, kidney, and central nervous system damage, <br /> .including hearing loss and visual disturbances <br /> Developmental: Exposure to toluene during pregnancy has <br /> demonstrated limited evidence of developmental toxicity in <br /> laboratory animals . The effects seen include decreased feral j <br /> body weight and increased skeletal variations in both inhalation ] <br /> and oral studies <br /> Ethyl Benzene (CAS## 100-41-4) <br /> Carc,inogenmcmty Rats and mice exposed to 0, 75, 250, or 750 ppm <br /> ethyl benzene in a two year inhalation study demonstrated <br /> limited evidence of kidney, liver, and lung cancer_ Ethyl <br /> benzene has not been listed as a carcinogen by NTP, IARC, or <br /> OSHA <br /> Target Organ (s) : In rats and mice exposed to 0, 75, 250, or 750 ppm <br /> ethyl benzene in a two year inhalation study there was mild <br /> damage to the kidney (tubular hyperplasia) , liver (eosinophilzo <br /> foci, hypertrophy, necrosis) , thyroid (hyperplasia) and <br /> Pituitary (hyperplasia) <br /> n-Hexane- (CAS# 110-54-3) <br /> Target Organs) Excessive exposure to n-hexane can result in <br /> peripheral neuropathies The initial symptoms are symmetrical <br /> sensory numbness and parestheszas of distal portions of the <br /> extremities . Motor weakness is typically observed in muscles of <br /> the toes and fingers but may also involve muscles of the arms, <br /> thighs and forearms . The onset of these symptoms may be <br /> delayed for several months to a year after the beginning of <br /> exposure The neurotoxic properties of n-hexane are potentiated . <br /> by exposure to methyl ethyl ketone and methyl isobutyl ketone <br /> Issue Date 03/29/99 Status Final Revised <br /> Revised Sections : 1, 2, 3, 4 , 5, 6, 7 , 8, 9, 11, 14 <br />