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I. <br /> ;"chnine httpahvw%+""'►f+u.cdu/jonesbtlexperiments/iloison/strychnine.htm <br /> Strychnine, (OMMN202) <br /> Strychnine is soluble with difficulty in water, its salts much more easily so. It is one of the <br /> most intensely bitter of the alkaloids It gives reactions in very dilute solutions with most <br /> of the general alkaloidal reagents. The chlorides of gold and platinum do not react in very <br /> " dilute solutions, perhaps, below 0.1 per cent. to 0.01 per cent. <br /> S 1. Strychnine forms a colorless solution with concentrated sulfuric acid. I <br /> j S2. To the dry substance add a drop of concentrated acid, about one part water to five <br /> parts of acid, then by means of a glass rod, draw through the solution a minute crystal of <br /> potassium dichromate. A series of colors results, always in the same order: first blue <br /> which quickly becomes violet, then more slowly red, pink, and yellow. The colors are <br /> characteristic of strychnine and, when the substance is pure will be produced by as small <br /> 1 an amount as fifty-thousandth of a grain. The reaction is, however, interfered with by the <br /> presence of a number of organic compounds, including morphine. <br /> S3. Vanadium sulfate in concentrated sulfuric acid dissolves the solid compounds with <br /> the production, first of a blue, followed by a violet and red color. If it is then diluted with <br /> R water the pink remains for a long time. <br /> ' S4. Cerium oxide with strychnine in concentrated sulfuric acid gives the same color as the <br /> last reagent. It is said to react with one millionth of a gram. To make the reagent, heat <br /> cerium oxalate to redness to form the oxide and dissolve this in thirty times its weight of <br /> j concentrated sulfuric acid. <br /> _I S5. Strychnine gives no color when treated with concen-trated sulfuric acid and a <br /> molybdate, nitrate, or nitric acid. <br /> S6. Concentrated nitric acid colors strychnine or its salts only faintly yellow, if at all, <br /> when it dissolves them, but on standing the solution becomes a darker yellow (difference <br /> from brucine). <br /> i <br /> i <br /> �1 of 1 1/26/00 9:36 AM s <br /> 3 <br />