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:XTOXNET PIP - IPRODIONE Page 2 0: beagle dogs fed dietary doses of about 2.3 mg/kg/day for 1 year showed liver and kidney weight increases. At dos starting at about 1.5 mg/kg/day, the dogs had decreased prostrate weights and changes within red blood cells (damage to the hemoglobin molecules). Females also had slight decreases in uterus weights. No effects were note( below 0.5 mg/kg/day dose [43]. • Reproductive effects: Female rats were fed iprodione over three successive generations showed no effects on reproduction at doses at and below 1.25 mg/kg/day [43]. Reductions in fertility and fecundity were not observed a doses of 5 mg/kg/day [43]. Based on these data, ioprodione is not likely to cause reproductive effects. • Teratogenic effects: There were no developmental effects noted in the offspring of pregnant rats receiving dietar; doses of about 5.4 mg/kg/day [43]. However, the dose rate of about 120 mg/kg/day elicited unspecified developmental toxicity in the rats [43]. Rabbits did not develop any dose-related toxicity at or below 2.7 mg/kg/da of iprodione,but did develop toxicity at 6 mg/kg/day [43]. It appears that iprodione is not likely to cause teratoger effects at expected exposure levels. • Mutagenic effects: No data are currently available. • Carcinogenic effects: A 2-year feeding experiment with rats showed no increases in tumor formation or tumor precursors(neoplastic foci) at dietary doses of about 2.5 mg/kg/day [43]. An 18-month study in mice showed cancer related effects at doses up to approximately 22 mg/kg/day [43]. Current evidence on the carcinogenicity of iprodione is inconclusive. • Organ toxicity: Target organs identified in animal studies include the reproductive system (prostate gland and uterus), liver, and kidneys. • Fate in humans and animals: No data are currently available [43]. :colouical Effects: • Effects on birds: Iprodione is slightly toxic to wildfowl. The reported acute oral LD50 in bobwhite quail is 930 mg/kg [1]. • Effects on aquatic organisms: Iprodione is moderately toxic to fish species, with LC50 values ranging from 2.25 mg/L in the sunfish to 6.7 mg/L in the rainbow trout [8]. Reported bioconeentration factors of 50 to 360 in carp an other fish species indicate low bioconcentration potential [8]. • Effects on other organisms: Iprodione is nontoxic to bees [1]. Mvironmental Fate: • Breakdown in soil and groundwater: The half-life of iprodione in soil ranges from less than 7 to greater than 60 days [l,l 11. A representative half-life in most soils is estimated to be 14 days [11]. Degradation rates vary with so' acidity, soil clay content, and history of the soil fungicide treatment. In soils that had been treated consistently wit] iprodione for 10 or more years, slow or little breakdown of the compound vinclozolin occurred, while in soil that had been treated with vinclozolin rapid degradation of vinclozolin and iprodione occurred [44]. Iprodione is slight soluble and moderately to well sorbed by most soils [11]. These properties, combined with its short field half-life indicate a low potential to contaminate groundwater. • Breakdown in water: The compound breaks down very rapidly in water under aerobic conditions;the rate is lesser, but still rapid under near-anaerobic conditions [8]. The compound is readily degraded by UV light. • Breakdown in vegetation: The compound is rapidly broken down in the plant after is taken up by the roots and translocated [1]. The main metabolite in plants is 3,5-dichloroaniline [1]. Iprodione alone or in combinations with several other fungicides was not toxic to plants (phytotoxic) [45]. "hysical Properties: • Appearance; Iprodione is a colorless,odorless crystal [1]. . Chemical Name: 3-(3,5-dichlorophenyi)-N-(1-methylethyl)2,4-dioxo-l-imidazoline-carboxamide [1] tttp://extoxnet.orst.edu/pips/iprodion.htm 7/2/20(