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permethrin(Ambush,Pounce)Chemical Profile 4/85 Page 3 of 5 <br /> DERMAL: LD' - >4000 mg/kg (rat) ; >2000 mg/kg ( pit) (56) . <br /> MiN1y irritating (20b) <br /> ORAL: LD50 = >4000 mg/kg (technical product) (56) <br /> Oral LD50 values of permethrin depend on such factors <br /> _ as: carrier, cis/trans ratio of the sample, the test <br /> species, its sex, age and degree of fasting. Values <br /> reported sometimes differ markedly. Typical values for <br /> a cis/trans ratio of C. 40:60 are: for rats 430-4000 <br /> r. mg/kg; for mice 540- 2690 mg/kg; for chickens >3000 <br /> mg/kg (62) . <br /> INHALATION: LC50 = >23.5 mg/liter of air (rat) (aerosol) (56) <br /> EYES: Mildly irritating (20b) . <br /> B. SUBACUTE AND CHRONIC TOXICITY: <br /> In 2-yr feeding trials rats receiving 100 mg/kg diet showed no <br /> ill-effect (62) . Permethrin is not mutagenic or teratogenic (20b) . <br /> r. IV. ENVIRONMENTAL CONSIDERATIONS <br /> Some hazard to fish, beneficial insects and honey bees. Biological <br /> magnification unlikely. Nonphytotoxic (1) . <br /> The acute oral LD50 for Japanese quail = >13,500 mg/kg; the LC50 (96 <br /> hr.) for rainbow trout is 9 ug/l (62) . <br /> The results. . . .indicate that permethrin is rapidly degraded in <br /> soil. Degradation of the trans isomer occurs more rapidly than with <br /> the cis isomer. The results obtained with enrichment and isolated <br /> cultures, and in soil experiments comparing nonsterile and sodium azide <br /> treated soils indicate that microbial metabolism is also involved (42) . <br /> Based on results obtained in identifying soil degradation products, <br /> it is apparent that the major degradation mechanism of permethrin is <br /> hydrolysis to the dichlorovinyl acid and 3-phenoxy benzyl alcohol <br /> moieties. Further metabolism of both products result in the evolution <br /> of the C-14 label as 14-CO2 (42) . <br /> Approximate Residual Period: 1-2 weeks on plants; weathers much better <br /> than natural pyrethroids. Immobile in soil; persistence more or less <br /> than 6 months (1) . <br /> V. EMERGENCY AND FIRST AID PROCEDURES <br /> The chemical information provided below has been condensed <br /> from original source documents, primarily from "Recognition and <br /> M> n1- r.f Doch-inirlc Dnicn»innc�� lrri orl his Tll+ >lA D M�r�>n <br /> .. which have been footnoted. This information has been provided in <br /> this form for your convenience and general guidance only. In <br /> specific cases, further consultation and reference may be required <br /> and is recommended. This information is not intended as a sub- <br /> stitute for a more exhaustive review of the literature nor for the <br /> judgement of a physician or other trained professional. <br /> If poisoning is suspected, do not wait for symptoms to develop. <br /> ` Contact a physician, the nearest hospital, or the nearest Poison <br /> Control Center. <br /> FREQUENT SYMPTOMS AND SIGNS OF UNDUE EXPOSURE TO PYRETHRUM, PYRETHRINS, <br /> PYRETHROIDS, AND PIPERONYL BUTOXIDE. <br /> A STUFFY, RUNNY NOSE and scratchy throat from inhalation of partly <br /> purified pyrethrum extract is the most common adverse effect of these <br /> agents. Asthmatic WHEEZING may be precipitated by exposure of <br /> predisposed individuals. Sudden bronchospasm, swelling of oral and <br /> laryngeal mucous membranes, and shock (anaphylaxis) have been reported <br /> after pyrethrum inhalation. Delayed appearance of dyspnea, cough and <br /> fever, with patchy lung infiltrates on x-ray, suggest hypersensitivity <br /> pneumonitis. Nervous irritability, tremors, and ataxia have occurred <br /> rarely in persons who have had massive inhalation exposure to <br /> http://pmep.cce.comell.edu/profiles/insect-mite/mevinphos-propargite/permethrir/insect-prof-permethrin.hf rd 10/30/2003 <br />