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propargite (Omite, Comite) r -nical Fact Sheet 9/86 Page 2 of 7 <br /> - Acute Oral Toxicity (Rat) : 2.2 g/kg <br /> - Acute Dermal Toxicity (Rabbit) : 3.16(1.63-6.15) ml/kg <br /> - Acute Inhalation: > 2.5 mg/l <br /> - Primary Eye Irritation: Corneal effects that were not reversible <br /> after 14 days were observed in four of six rabbits. <br /> - Dermal Sensitization: Inconclusive <br /> - Subchronic Dermal Toxicity: Inconclusive <br /> - Chronic Effects <br /> - Teratogenicity (Rabbit) : Maternal NOEL = 2 mg/kg/day. Maternal <br /> LEL s 6 mg/kg/day (reduced body weight gain) . Developmental <br /> Toxicity NOEL = 2 mg/kg/day; developmental (increased resorption, <br /> reduced body weight, and delayed ossification) . A/D ratio = <br /> maternal LEL/Developmental = 2/2 = 1. <br /> - 3-Gen. Reproduction (Rat) : Noel > 300 ppm. Additional <br /> data is required. Only one dose used throughout the study. <br /> - Mutagenicity: Inconclusive. Additional categories of <br /> mutagenicity testing are required. <br /> - Chronic Feeding/Oncogenicity (Dog) : NOEL = 900 ppm (HDT) . No <br /> adverse effects were observed by the hematology, blood chemistry <br /> determinations or urine examinations. <br /> - Feeding/Oncogenicity: Inconclusive. The study is classified as <br /> Supplementary because too few animals were examined histologically <br /> at 900 and 2000 ppm. This study needs to be repeated. <br /> - Metabolism: Inconclusive. Additional data is required. <br /> - Other Toxicological Effects <br /> - Propargite is not an organophosphate chemical; therefore, it does <br /> not have a neurotoxic potential, and a neurotoxicity study is not <br /> required. <br /> - Major Routes of Exposure <br /> - There is a potential for dermal, ocular and inhalation exposure <br /> from mixing concentrates and applying spray mixtures. <br /> Physiological and biochemical behavior characteristics <br /> - Foliar Absorption: Data are not available to evaluate the effects <br /> of propargite in plants. <br /> - Translocation: Data are not available to evaluate the translocation <br /> in plants. <br /> - Mechanism of Pesticidal Actions: Mode of activity involves residual <br /> killing action. <br /> Environmental Characteristics <br /> Available data are insufficient to fully assess the environmental <br /> fate of propargite. From the data that exists, however, there seems <br /> to be no reason for concern about the leaching of the parent <br /> chemical into groundwater. <br /> Ecological Characteristics <br /> - Avian Oral Toxicity: Mallard duck - > 4640 ppm. <br /> - Avian Dietary Toxicity: Bobwhite quail - 3401 ppm; <br /> Mallard duck - > 4640 ppm. <br /> - Avian Reproduction: Data are inconclusive to determine the effects <br /> on avian reproduction. Additional data are required. <br /> - Freshwater Fish Toxicity: Bluegill Sunfish - 0.167 ppm; <br /> Rainbow trout - 0.118 ppm. <br /> - Aquatic Invertebrates (freshwater) : Daphnia magna - 0.092 ppm. <br /> - Aquatic Invertebrates (lifecycle) : Daphia magna - 0.009 - 0.014 ppm. <br /> - Available data indicate that propargite is practically nontoxic to <br /> avian species. Propargite is highly toxic to fish. <br /> Tolerance Assessment <br /> http://pmep.cce.cornell.edu/profiles/insect-mite/mevinphos-propargite/propargite/insect-pr... 9/26/2004 <br />