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propargite (Omite, Comite) I mical Fact Sheet 9/86 Page 4 of 7 <br /> ... <br /> MAW <br /> Therefore, the public should be in no danger from dietary exposure <br /> while the Agency awaits data. <br /> Problems Known to Have Occurred with Use of the Chemical <br /> N/A <br /> Summary Science Statement <br /> Propargite is not considered at this time to be oncogenic. Propargite <br /> has a low acute (Category III) oral, dermal, inhalation toxicity. It <br /> is in toxicity category I however, for primary eye and primary skin <br /> irritation, and cases of severe dermatitis afflicting workers <br /> reentering treated sites have been reported. Chronic testing reveals <br /> that propargite appears to have little effect on laboratory animals <br /> except at higher dosage levels; effects reported include depressed <br /> body weights and rates of weight gain. Oral subchronic test results <br /> appear to parallel those for chronic testing. Propargite is not <br /> teratogenic in rabbits and rats. Insufficient data exist to fully <br /> assess the dermal sensitization, subchronic dermal toxicity, <br /> subchronic inhalation toxicity, and mutagenicity of propargite. <br /> Additional metabolism testing is also necessary. Propargite is <br /> relatively nontoxic to honey bees and avian species. It is very <br /> highly toxic to freshwater fish. The actual threat to aquatic <br /> organisms at this time cannot be accurately assessed due to the <br /> insufficiency of environmental fate data. Field monitoring data to <br /> determine propargite residues in water from terrestrial applications <br /> is needed as is additional testing to determine the effects of end-use <br /> products on coldwater and warmwater species of fish, aquatic <br /> invertebrates, and estuarine and marine organisms. The metabolism of <br /> propargite in both plants and animals is not sufficiently understood; <br /> additional metabolism data are necessary. Storage stability data are <br /> also necessary, as well as additional crop residue data and processing <br /> ' studies for certain crops registered for propargite use. <br /> 4. SUMMARY OF REGULATORY POSITIONS AND RATIONALES <br /> - The following are warning statements that must be included on <br /> propargite pesticide labels. <br /> _ - Manufacturing Use Products <br /> - Under the Environmental Hazard Statement, add the following <br /> precaution. <br /> "This pesticide is toxic to fish. Do not discharge effluent <br /> containing this product into lakes, streams, ponds, estuaries, <br /> oceans, or public water unless this product is specifically <br /> identified and addressed in an NPDES permit. Do not discharge <br /> effluent containing this product into sewer systems without <br /> previously notifying the sewage treatment plant authority. <br /> for guidance, contact your State Water Board or Regional <br /> Office of the EPA." <br /> - Protective Clothing Statement <br /> "Mixer/loaders must wear goggles or a face shield, chemical- <br /> resistant apron, long-sleeved shirt and long pants or <br /> coveralls, and mid-forearm to elbow length chemical-resistant <br /> gloves when mixing, loading, or otherwise handling the <br /> concentrate." <br /> - End-Use Products <br /> http://pmep.cce.comell.edu/pro fi le s/insect-mite/mevinphos-propargite/propargite/insect-pr... 9/26/2004 <br />