|
propargite (Omite, Comite) c mical Fact Sheet 9/86 Page 7 of 7
<br /> *41200
<br /> 6. CONTACT PERSON AT EPA
<br /> George T. LaRocca
<br /> Product Manager Number 15
<br /> U.S. Environmental Protection Agency
<br /> TX-767C
<br /> 401 M Street. S.W.
<br /> r. Washington, D.C. 20460
<br /> (703) 557-2400
<br /> DISCLAIMER: THE INFORMATION PRESENTED IN THIS CHEMICAL INFORMATION FACT
<br /> SHEET IS FOR INFORMATIONAL PURPOSES ONLY AND NOT TO BE USED TO FULFILL
<br /> DATA REQUIREMENTS FOR PESTICIDE REGISTRATION AND REREGISTRATION.
<br /> To Top
<br /> . __._ _,.__ ..... ......_. __.._..... _.. .. .... - _ ........
<br /> For more information relative to pesticides and their use,please contact 5123 Comstock Hall
<br /> the PMEP staff at: Comell University
<br /> Ithaca,New York 14853-0901
<br /> (607)-255-1866
<br /> Last Modified:03/01/2001
<br /> Questions regarding the information and development within this web site should be directed to the PMEP Webmaster.
<br /> ©2004 Cornell University
<br /> Disclaimer:Please read the pesticide label prior to use.The information contained at this web site is not a substitute for a pesticide
<br /> label.Trade names used herein are for convenience only.No endorsement of products is intended,nor is criticism of unnamed
<br /> products implied.
<br /> i.
<br /> 2,4-D Page 1 of 2
<br /> PMEP Home Paec P Pesticide Active Ingredient Information V EXTOXNET:The Extension Toxicology Network V2.4-1)to Captan V2,4-D
<br /> EXT0X_NET
<br /> Extension Toxicology Network
<br /> A Pesticide Information Project of Cooperative Extension Offices of Cornell University,Michigan State University,Oregon State
<br /> University,and University of California at Davis.Major support and funding was provided by the USDA/Extension Service/National
<br /> Agricultural Pesticide Impact Assessment Program.
<br /> Pesticide ^2, _D
<br /> Information `f
<br /> Profile Publication Date:9/93
<br /> TRADE OR OTHER NAMES
<br /> 2,4-D is used in many commercial products.A few commercial names for products containing 2,4-D include Weedtrine-II,
<br /> -- Aqua-Kleen,Barrage,Plantgard,Lawn-Keep,Planotox and Malerbane.
<br /> INTRODUCTION
<br /> 2,4-D,a chlorinated phenoxy compound,functions as a systemic herbicide and is used to control many types of broadleaf
<br /> weeds.There are many forms or derivatives(esters,amines,salts)of 2,4-D and these vary in solubility and volatility.Unless
<br /> otherwise specified,this document will refer to the acid form of 2,4-D.This compound is used in cultivated agriculture and in
<br /> r. pasture and rangeland applications,forest management,home and garden situations and for the control of aquatic vegetation.
<br /> 2,4-D was a major component(about 50%)of the product Agent Orange used extensively throughout Vietnam.However
<br /> most of the problems associated with the use of Agent Orange were associated with a contaminant(dioxin)in the 2,4,5-T
<br /> y component of the defoliant.The association of 2,4-D with Agent Orange has prompted a vast amount of study on the
<br /> herbicide.
<br /> TOXICOLOGICAL EFFECTS
<br /> ACUTE TOXICITY
<br /> While the LD50 of 2,4-D suggests that it is only moderately toxic,the product carries the DANGER signal word on the label
<br /> indicating that it is highly toxic.This is because 2,4-D has produced serious eye and skin irritation among agricultural
<br /> workers(15,16).
<br /> The oral LD50 of 2,4-D in the rat ranges from 375 to 666 mg/kg;370 mg/kg in the mouse;and less than 320 to 1,000 mg/kg
<br /> in the guinea pig.The rat and rabbit have dermal LD50 values of 1,500 mg/kg and 1,400 mg/kg,respectively.In humans,
<br /> prolonged breathing of 2,4-D causes coughing,burning,dizziness,and temporary loss of muscle coordination.
<br /> Symptoms of poisoning can be fatigue and weakness with perhaps nausea.On rare occasions there can be inflammation of
<br /> the nerve endings with muscular effects following high levels of exposure(6). Symptoms vary with the different commercial
<br /> products because of the specific amounts and types of additives such as surfactants and solvents.
<br /> CHRONIC TOXICITY
<br /> Rats given moderate amounts(50 mg/kg)of 2,4-D in the diet for two years had no adverse effects. Some dogs fed lower
<br /> amounts of the compound in their food for two years died,probably because dogs do not excrete organic acids efficiently.A
<br /> human given a total of 16.3 grams in 32 days as"desperation therapy"lapsed into a stupor,showed signs of incoordination,
<br /> weak reflexes,and urinary incontinence.
<br /> http://pmep.cce.comell.edu/profiles/extoxnet/24d-captan/24d-ext.html 9/26/2004
<br />
|