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EXTOXNET PIP- SETHOXYDIM Page 1 EXTOXNET Extension Toxicology Network Pesticide Information Profiles A Pesticide Information Project of Cooperative Extension Offices of Cornell University, Oregon State University, the University of Idaho, and the University of California at Davis and the Institute for Environmental Toxicology, 'Michigan State University. Major support and funding was provided by the USDA/Extension Service/National Agricultural Pesticide Impact Assessment Program. 'EXTOXNET primary files maintained and archived at Oregon State University Revised June 1996 ` Sethoxydim low Trade and Other Names: Trade names include Aljaden,Alloxol S, BAS 9052H, Checkmate, Expand, Fervinal, •..rrasidim, Nabu, NP-55, Poast, Tritex-Extra, and Vantage. Regulatory Status: Sethoxydim is a General Use Pesticide (GUP). It is in EPA toxicity class III - slightly toxic. '?roducts containing sethoxydim bear the Signal Word CAUTION on the label. Chemical Class:Not Available Introduction: Sethoxydim is a selective post-emergence herbicide used to control annual and perennial grass weeds ..n broad-leaved vegetable, fruit, field, and ornamental crops. It also has indoor uses. It is available in emulsifiable concentrate formulations. —=ormulation: It is available in emulsifiable concentrate formulations. Toxicological Effects: • Acute toxicity: Sethoxydim is slightly toxic by ingestion, and practically nontoxic by dermal absorption [58]. It causes skin and eye irritation. Inhalation of dusts or vapors can cause irritation of the throat and nose [58]. Other symptoms of poisoning include incoordination, sedation, tears, salivation, tremors, blood in the urine, and diarrhea [58]. Sethoxydim does not cause allergic skin reactions [3]. The oral LD50 for sethoxydim in rats is 2600 to 3100 mg/kg [1,58]. The dermal LD50 in rats is greater than 5000 mg/kg (1,58) and the 4-hour inhalation I" LC50 for sethoxydim in rats is greater than 6.3 mg/L [1]. • Chronic toxicity: Long-term contact with sethoxydim can cause redness and swelling of the eyes or skin [8]. No adverse effects were observed in mice given 2, 6, or 18 mg/kg/day for 2 years [58,126]. In a 1-year dog feeding study, doses above 8.86 mg/kg/day in males and 9.41 mg/kg/day in females produced anemia [13,58]. • Reproductive effects: When pregnant rabbits were fed 40, 160, or 480 mg/kg/day, decreased litter size, low fetal weights, severe maternal weight loss, increased fetal resorptions, spontaneous abortions, and maternal deaths occurred at the 480 mg/kg level [126]. Based on this study, reproductive effects are unlikely in humans at expected exposure levels.