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Human Health Risk Assessment <br /> Former Mobil Oil Bulk Plant 04-343 <br /> 500 East Grant Line Road <br /> Tracy, California <br /> s <br /> Components of Risk Assessment <br /> ' The risk assessment process is usually divided into four steps. A description of each of these <br /> steps is provided below: <br /> ' HAZARD IDENTIFICATION <br /> This component involves gathering and evaluating data on the types of health injury or disease <br /> that may be produced by a chemical and on the conditions of exposure; under which injury or <br /> disease is produced. It may also involve characterization of the behavior of the chemical within <br /> the environment and within the body and the interactions of the chemical with organs, cells, or <br /> even parts of the cells. This information may be useful in answering the question of whether <br /> ' the forms of toxicity known to be produced by a substance in one population (e.g., animals) are <br /> also likely to be produced in humans. In essence the hazard identification answers the question <br /> ' of whether the chemical is capable of inducing some type of adverse health effect in potentially <br /> exposed human populations <br /> DOSE-RESPONSE ASSESSMENT <br /> Describes the quantitative relationship between the exposure to a chemical and the extent of the <br /> health effect. The quantitative dose-response relationship is often derii ed from animal studies. <br /> ' Data are derived from animal studies or, less frequently, from str.dies in exposed human <br /> populations. There may be many different dose-response relationships for a substance if it <br /> ' produces different toxic effects under different conditions of exposure_ The risks of a substance <br /> can not be determined with any degree of confidence unless dose-response relations are <br /> quantified, even if the substance is known to be "toxic." <br /> EXPOSURE ASSESSMENT <br />' Thisortion of the risk p s assessment describes the nature of the population exposed to a substance <br />' and the duration and magnitude of the exposure. The evaluation may involve past, current, or <br /> anticipated future exposures. <br /> Y 30-0136-11 <br /> 1-16 i <br />