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w • .. . 1. � w.. � w -/ v.. J 4 .� L J ` � -.I 4 r � 1L�� Vr -J ►. .J �1 �J 3. Hazards Identification Health Hazard Data: 1. The major effect of exposure to this product is central nervous system depression and polyneuropathy. 2. Studies have shown that repeated exposure of laboratory animals to high concentrations of whole gasoline vapors at 67,262 and 2056 ppm has caused kidney damage and cancer of the kidney in rats and liver cancer in mice. 3. LARC has listed gasoline as possibly carcinogenic(2B)to humans with limited evidence in humans in the absence of sufficient evidence in experimental animals. NIOSH lists gasoline as a carcinogen with no further classification. 4. N-heptane and cyclohexane cause narcosis and irritation of eyes and mucous membranes. Cyclohexane has been reported to cause liver and kidney changes in rabbits. N-heptane has been reported to cause polyneuritis following prolonged exposure. 5.ACGIH lists benzene a human carcinogen with and assigned TLV of 0.5 ppm 8 hour TWA and a STEL of 2.5 ppm; IARC, NTP $ OSHA show sufficient evidence for classifying Benzene as a human carcinogen, see 29 CGR 1910.1028 for current PEL of 1 ppm and specific actions to take. Studies have shown that benzene can induce leukemia at concentrations as low as 1 ppm. Significant elevations of chromosomal aberrations have been corroborated among workers exposed to levels at mean concentrations less than 10 ppm. Based on risk assessment studies by Rinsky, an individual inhaling 1 ppm of benzene for 40 years, the odds of benzene- induced leukemic death were 1.7 times higher than those of unexposed workers. 6. MTBE is a mild irritant to the eye with an LC50 of 85 mg/m3 on 4 hr. exposure and an LD50—4 ml/Kg (RATS). An increase in anesthesia with increasing concentration (250,500 & 1000 ppm )was observed during a 90 day Test exposure. ACGIH has listed MTBE as an animal carcinogen (A3) based on tests in experimental animals at relatively high dose levels, by routes of administration, at sites, of histologic types, or by mechanisms not considered relevant to worker exposure.Available evidence suggests that MTBE is not likely to cause cancer in humans except under uncommon or unlikely routes of levels of exposure. 7.Trimethyl benzene (pseudocumene (1,2,4,)&mesitylene (1,2,5,)) has a PEL and TLV of 25 ppm 8 hr. TWA; the isomers may cause nervousness, tension, and anxiety and asthmatic bronchitis. 8. n-Hexane has been shown to cause polyneuropathy(peripheral nerve damage)after repeated and prolonged exposure, other hexanes show narcotic effects at 1000 ppm and are not metabolized like n-hexane.