Laserfiche WebLink
Product Name: Gasoline with Ethanol <br /> Page 12 of 15 1 <br /> Product Code : Multiple <br /> Mutagenicity: Excessive consumption of alcoholic beverages has been <br /> associated with chromosomal aberrations in white blood cells . <br /> Depending on the animal species being tested, ethanol may <br /> produce chromosomal damage, DNA damage and mutation in both <br /> somatic and germ cells . <br /> Toluene (CAS# 108-88-3) <br /> Target Organ(s) : Epidemiology studies suggest that chronic <br /> occupational overexposure to toluene may damage color vision. <br /> Subchronic and chronic inhalation studies with toluene produced <br /> kidney and liver damage, hearing loss and central nervous system <br /> (brain) damage in laboratory animals . Intentional misuse by <br /> deliberate inhalation of high concentrations of toluene has been <br /> shown to cause liver, kidney, and central nervous system damage, <br /> including hearing loss and visual disturbances . <br /> Developmental: Exposure to toluene during pregnancy has <br /> demonstrated limited evidence of developmental toxicity in <br /> laboratory animals . The effects seen include decreased fetal <br /> body weight and increased skeletal variations in both inhalation <br /> and oral studies . t r _ <br /> Ethyl Benzene (CAS# 100-41-4) <br /> Carcinogenicity: Rats and mice exposed to 0, 75, 250, or 750 ppm E <br /> ethyl benzene in a two year inhalation study demonstrated f <br /> limited evidence of kidney, liver, and lung cancer. Ethyl <br /> benzene has not been listed as a carcinogen by NTP, IARC, or <br /> OSHA. <br /> f <br /> Target Organ(s) : In rats and mice exposed to 0, 75, . 250, or 750 ppm <br /> ethyl benzene in a two year inhalation study there was mild <br /> damage to the kidney (tubular hyperplasia) , liver (eosinophilio <br /> foci, hypertrophy, necrosis) , thyroid (hyperplasia) and <br /> pituitary (hyperplasia) . <br /> n-Hexane (CAS# 110-54-3) <br /> Target Organ (s) : Excessive exposure to n-hexane can result in <br /> peripheral neuropathies . The initial symptoms are symmetrical <br /> sensory numbness and paresthesias of distal portions of the <br /> extremities . Motor weakness is typically observed in muscles of <br /> the toes and fingers but may also involve muscles of the arms, <br /> thighs and forearms . The onset of these symptoms may be I <br /> delayed for several months to a year after the beginning of <br /> exposure . The neurotoxic properties of n-hexane are potentiated '...:' <br /> by exposure to methyl ethyl ketone and methyl isobutyl acetone . <br /> Issue Date: 03/29/99 Status: Final <br /> Revised <br /> Revised Sections : 1, 2, 3, 4 , 5, 6, 7, 8, 9, 11, 14 <br />