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i Research on Cancer (IARC) , and the Occupational Safety and Health Administration (OSHA) Benzene may produce blood changes which include reduced platelets, red blood cells, and white blood cells Also, aplastic anemia, and acute nonlymphotic leukemia Benzene has produced fetal death in laboratory animals and caused chromosome changes in humans and mutation changes in cells of other organisms Laboratory animals have exhibited a higher degree of narcosis when exposed to both butane and butylene (additive effect) , than the degree of narcosis exhibited following exposure to butane or butylene alone Isopentane did not produce kidney damage in a subchronic oral laboratory study or in a subchronic inhalation exposure to 4500 ppm and 1000 ppm of a 50/50 mixture of isobutane and isopentane Exposure of pregnant rats during gestation to toluene at levels 250 ppm and higher produced some maternal toxicity and embryo/fetotoxicity A lifetime inhalation study in rats did not show any toxic effects even at the high dose of 300 ppm Behavioural signs of hearing loss were observed in rats exposed to toluene subchronically at levels of 1000 ppm or more Comparable effects have not been reported in humans Rabbits exposed eight hours per day, for forty days, to 762-6296 ppm cyclohexane showed no significant effects to the kidney, liver, heart, lungs, spleen, adrenals, intestines or brain Isooctane (2,2,4-Trimethylpentane) , a component of this product, has produced kidney damage in male rats only in a subchronic oral laboratory study No comparable health hazard for kidney disease is known to occur in humans Other Health Effects: Combustion, a normal use of gasoline, results in an exhaust that has been associated with skin cancer in laboratory animals Skin cancer was observed in these animals when exhaust was concentrated and repeatedly applied to the skin It is unknown if this route of exposure is relevant to human exposure Combustion (burning) of most carbon-containing material forms carbon monoxide Carbon monoxide inhalation may cause carboxyhemoglobinemia Chronic exposure to carbon monoxide causes fatigue, poor memory, loss of sensation in fingers, visual disturbances and insomnia Carboxyhemoglobinemia is frequently misdiagnosed as flu Sensitive sub-populations to the inhalation of carbon monoxide exist Carbon monoxide displaces oxygen in the bloodstream and therefore, can adversely effect people with pre-existing heart disease, pregnant women and smokers Fuels containing lead anti-knock compounds should be handled in such