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Product Safety Assessment:DO WT"' CMIT/MIT--Based Antimicrobial Products • KATHONTm 7G Antimicrobial PROCLIN 200 • LEGEND TM MK microbicide • PROCLIN 300 • PROCLINTm 150 Back to top Product Overview • DOWM CMITIMIT-based antimicrobial products are a series of broad-spectrum, formaldehyde-free biocides based on a mixture of active ingredients: 5-chloro-2-methyl-2H- isothiazol-3-one and 2-methyl-2H-isothiazol-3-one(CMIT/MIT)in a 3 to 1 ratio.These products are marketed by The Dow Chemical Company and its wholly-owned subsidiary,the Rohm and Haas Company,under the trade names KATHONTm antimicrobials,biocides, microbicides, microbiocides or preservatives;PROCLIN TM preservatives,BIOBANTM CM antimicrobials;CANGUARDTM CM preservatives;and AQUCARTM CM antimicrobials.6 2For further details,see Product Description. • DOW CMIT/MIT-based antimicrobial products are used in water-based adhesives,paints, coatings and inks, household cleaning products,construction materials,polymer emulsions, personal-care products,diagnostic reagents, paper-coating materials, industrial water-treatment, paper mill slimicides, metalworking fluids, oil and gas fluids.'2.3.4,5 For further details,see Product Uses. • DOWTM CMIT/MIT-based antimicrobial products are produced,distributed, and stored, in closed systems. Personnel working with these products in manufacturing operations could be exposed during maintenance,sampling,testing,or other procedures.Consumers could be exposed to very low levels in household cleaners or personal-care products.67 For further details,see Exposure Potential. • Eye contact with concentrated biocides may cause severe irritation or chemical burns with corneal injury,which may result in permanent impairment of vision,even blindness. Prolonged skin contact with concentrated biocides may cause chemical burns(skin corrosion). Prolonged or widespread skin contact may result in skin sensitization.These products have moderate toxicity if swallowed.Vapor or mist may cause irritation of the upper respiratory tract and lungs.6 For further details,see Health Information. • The active ingredients in DOW CMIT/MIT-based antimicrobial products are unlikely to accumulate in the food chain(low bioconcentration potential).They are completely soluble in water and do not bind to soil.Therefore,in the environment,CMIT and MIT tend to partition to water.CMIT and MIT are quickly biodegraded in soil,water or in sediments.They are also removed by biological wastewater-treatment processes.The active ingredients are very toxic to aquatic organisms on an acute basis.6 For further details,see Environmental Information. • DOW CMIT/MIT-based antimicrobial products are stable at recommended storage and use temperatures.At temperatures above 50°C(122°F),generation of gases can cause rapid pressure build-up in closed systems.Avoid temperatures above 40°C(104°F),and contact with amines,mercaptans,oxidizers,and reducing agents.6For further details,see Physical Hazard Information. Back to top Manufacture of Product8,2 • Capacity—Dow and its strategic partners produce DOWTm CMIT/MIT-based antimicrobial products at several global sites. • Process—The active ingredients CMIT and MIT are produced via a series of proprietary reactions and purification steps.The structures of the two active ingredients of the mixture are shown below. ®TMTrademark of The Dow Chemical Company("Dow")or an affiliated company of Dow Created:December 17,2010 The Dow Chemical Company Page 2 of 8