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Product Safety Assessment:DO WT"" CMIT/MIT--Based Antimicrobial Products The information that follows is based on data from concentrated biocide products. Harmful effects decrease as the concentration of active ingredients 5-chlor-2-methyl-4-isothiazolin-3-one(CMIT) and 2-methyl-4-isothiazolin-3-one(MIT)decreases.Therefore,the health risks associated with final product concentrations(less than 50 parts per million for consumer products)are very low compared to the concentrated active ingredient hazards listed below.Always read the product information before use and follow the label/use instructions. Eye contact—Contact may cause severe eye irritation or chemical burns with corneal injury, which may result in permanent impairment of vision,even blindness. Skin contact—Prolonged contact may cause skin burns with symptoms of pain severe local redness,swelling,and tissue damage. Prolonged or widespread contact may result in allergic skin reactions. Ingestion—These products have moderate toxicity if swallowed.Small amounts swallowed incidental to normal handling operations are not likely to cause injury. However,large amount may cause serious injury,even death. Inhalation—Vapor or mist may cause irritation of the upper respiratory tract(nose and throat) and lungs. Repeated exposure—Repeated exposure is not expected to cause additional significant adverse effects. Other—Similar materials have not caused cancer,birth defects,or fetal effects in animal testing. For more information,see the relevant Safety Data Sheet. Back to top Environmental Information 6,3 5-Chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one,the active ingredients in DOWTM CMIT/MIT antimicrobial products, have a low bioconcentration potential(tendency to accumulate in the food chain)and a high potential for mobility in soil.They are completely soluble in water. In the environment these compounds would tend to partition into water where they would rapidly biodegrade to non-persistent substances which are several orders of magnitude less toxic than parent compound.They would also be removed by common biological wastewater treatment facilities.These compounds are very toxic to aquatic organisms on an acute basis. For more information,see the relevant Safety Data Sheet. Back to top Physical Hazard Information 6,3 DOWT"'CMIT/MIT-based antimicrobial products are stable at recommended storage and use temperatures.The active ingredients can decompose violently at temperatures above 50°C (122°F).Generation of gases(hydrogen chloride, nitrogen oxides,sulfur oxides)can cause rapid pressure build-up in closed systems.Avoid temperatures above 40°C(104°F).Avoid contact with amines,mercaptans,oxidizers,and reducing agents. For more information,see the relevant Safety Data Sheet. Back to top "Trademark of The Dow Chemical Company("Dow")or an affiliated company of Dow Created:December 17,2010 The Dow Chemical Company Page 5 of 8