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Material Safety Data Sheet <br />Material Name: Autoguard DOT 3 Brake Fluid ID: AG -003 <br />and eye irritant. Ethylene glycol is absorbed through the skin. Ingestion of large amounts has produced kidney damage, <br />metabolic acidosis, renal failure, heart failure and pulmonary edema. Exposure to ethylene glycol may result in the <br />accumulation of calcium oxalate crystals in the kidney or brain. Ethylene glycol is a central nervous system depressant <br />characterized by headache, dizziness, nausea, weakness, loss of judgement and coordination, coma and even death at high <br />doses. <br />B: Component Analysis - LD50/LC50 <br />Triethylene glycol, monobutyl ether (143-22-6) <br />Dermal LD50 Rabbit: 3540 uL/kg <br />Oral LD50 Rat: 5300 mg/kg <br />Diethylene glycol monobutyl ether (112-34-5) <br />Oral LD50 Mouse: 2400 mg/kg <br />Oral LD50 Rat: 5660 mg/kg <br />Dermal LD50 Rabbit: 2700 mg/kg <br />Diethylene glycol (111-46-6) <br />Oral LD50 Rat: 12565 mg/kg <br />Oral LD50 Mouse: 23700 mg/kg <br />Dermal LD50 Rabbit: 11890 mg/kg <br />Triethylene glycol monoethyl ether (112-50-5) <br />Dermal LD50 Rabbit: 8 mL/kg <br />Oral LD50 Mouse: 5799 mg/kg <br />Oral LD50 Rat: 7750 mg/kg <br />Diethylene glycol monoethyl ether (111-90-0) <br />Oral LD50 Rat: 5500 mg/kg <br />Carcinogenicity <br />A: General Product Information <br />No data available on the product as a whole. Diethylene glycol given orally to rats and mice resulted in tumors of the <br />kidney, bladder and blood. <br />B: Component Carcinogenicity <br />None of this product's components are listed by ACGIH, IARC, OSHA, NIOSH, or NTP. <br />Epidemiology <br />No data available for product. <br />Neurotoxicity <br />No information available for the product. Diethylene glycol is a central nervous system and respiratory depressant. <br />Ethylene glycol may be present as a contaminant. Ethylene glycol is a central nervous system depressant. Symptoms <br />include ethanol -like intoxication, ataxia, slurred speech, seizures and coma. <br />Mutagenicity <br />No data available on this product as a whole. <br />Teratogenicity <br />No information available for the product. Reproductive effects have been reported for diethylene glycol. When given orally <br />to rats diethylene glycol was fetotoxic and caused musculoskeletal abnormalities. In mice, diethylene glycol resulted in <br />fetal death and affected female fertility. Triethylene glycol monomethyl ether (TGME) produced testicular effects in rats in <br />a 90 day drinking water study. Increased skeletal variations were reported in an developmental study in rats. Ethylene <br />glycol may be present as a contaminant in this product. Ethylene glycol has been fetotoxic, caused developmental <br />abnormalities and maternal effects in laboratory mice and rats. <br />Other Toxicological Information <br />No other information available. <br />11 * * * Section 12 - Ecological Information <br />Ecotoxicity <br />A: General Product Information <br />No information is available on ecotoxicity of this product. <br />B: Ecotoxicity - Aquatic Toxicity <br />Page 4 of 6 Issue Date: 04/28/97 Revision: 1.0001 Print Date: 03/04/99 <br />