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Benzene <br /> ` S-1?21 <br /> Pdge 3 <br /> SECTION IV. LONG-TERM ORGANISM THREAT POTENTIAL <br /> Carcinooenic <br /> pR ; L�m�ted evidence of carcinogenic effects in animals. Sufficient <br /> r evidence of carcinogenic effects in humans. <br /> NTPINCI: N-IPINCI has reported carcinogenic effects. <br /> ZZ AG has reported carcinogenic effects. ses <br /> Fu—mans andrrat59enic Carcinagenic by RTECsacbritedrianincmice,°f leukemia in <br /> Muta enicit ins acts, or mouse lymphoma <br /> AR ,Not mutagenic in bacteria, yeast, <br /> cel-Ts. Chromosomal anomalies in humans, rats, and mice were Observed. <br /> RTECS: Positivered mutagenic <br /> enDNA responses <br /> a inrats, <br /> and chromosomal breaks in humans <br /> raoolts were observed. <br /> bobse <br /> were observed. <br /> Terato eni ci t jaw and absece of Lh <br /> abnormal <br /> tinsmi elef B ainaand ske' letalndefects in rats rwere <br /> were defects obser <br /> observed. Other studies did not show teratogenic teffects <br /> and other effects <br /> Eva RTECS: Abnormalities of the musculoskeletal sys <br /> on the newborn were observed in rats and mice. <br /> Reproductive Effects <br /> teration of estrus cycles in rats was observed. Increased <br /> testi cul ar weight rabbi tsge <br /> and were tobse ion of ed he Fetotox seminiferous i ty in tubules rats, <br /> rats andmice <br /> guinea pigs, and <br /> were observed, and extra ernoryonic <br /> RTECS; Fetotoxicity, post-implantation mortality, <br /> structures in rats and mice were obser`red. Pre-implantation rort3iity, <br /> effects in mice were observed. <br /> fetal death, and other fetal <br /> -ION `r. CHRONIC TOXICITY ;,, _:{ ses5 leacat•1es, <br /> 5EC cue, ��usc, _ Ne.. • <br /> appetite joss, geirLIZ +oss , sat ^e 7i -ev�r;+ble 7i0od ^ge5 , <br /> r <br /> dizziness nervousness , irrit3b' ' , `, <br /> r and damage to the heart and liver. <br /> S---C-:'0tl VI, PH'fSiCnL DATA <br /> :0 a <br /> ;vaocrat:LrMnate ,3u'vi :G3�a�a = - _.. <br /> \01 pfl �'I1' 7 fat �0tt �� 71 3=a! ,n <br /> a0 f'1p7�4 .:OIJ0711�'.: � y•. �' a-':, ,1C',: .3,��:C�1;_, J7 �5 . <br /> 1 5 1 'u2. Cwr,Cn ^1G" 'J•i a �'Of`: S: ,C an JCC' <br /> Aooear ince a,-.cOdCr: C l ear ::C , ' <br /> W rasn0'a 0-. 0 pCm• <br /> Copyrignt 1984 by _nvirologic Oars, Inc. <br /> 4.57 <br />