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:ISDs
<br /> ?age 3
<br /> SECTION IV. LONG-TER ORGAN I :4 THREA' POTEN71 +L
<br /> Carcinooenicity
<br /> !ARL: L.lilll-al !videnca Or Car-1.nogen i c er."ec�; in anina's SUC-ici-�nt
<br /> epience of carcino:pnic of`ecw$ in hurnans.
<br /> {TPINC; "lTal`IC: has reoor:ad -arcinocenic ?r;ects.
<br /> Tti T•
<br /> nds reported car,inagenic; dr`2CL5. _
<br /> CS' CTrcinogen�ic by R'ECs criteria based on cas-s of I.u<emla in
<br /> nunans ;Inc rats, Carcinogenic by 417ECS criteria in mica.
<br /> —_ <<rL`tacenicl tJ
<br /> 1nR� aL mUt3Cen1C 1n bacteria, yeast, insec:s, or mouse lymphoma
<br /> eel 5. Chromosomal ano,r 11 ies in humans, rats, anc dice .Vere coserved.
<br /> c;rOS: Positive mutagenic responses in bacteria, ..ice, rats, and
<br /> r.aaolts 'dere observed. CNA damage and chromosomal breaks in humans
<br /> 'dere observed.
<br /> ieratoaenicity
<br /> LARL: iali atncrma1 ities, cla�t palate, and absEnc--, or the ic'�rcr
<br /> N3!? je,ec:s Observed in ,ilio. Brain and skeleta'r de-fects in rats .Very
<br /> obs-"rued. Other studias did not show ter•atocenic effects.
<br /> RTE'S: Abnormalities Of :he ;tusculcskelatal syste:a and other er'lec.s
<br /> on the newoorn aer' obser':ea in rats and .lice.
<br /> - Reoroductive E-`ecs
<br /> l it Aiterat?on or estrus cycles in rats was cosarveo. increased
<br /> Lt?s:icular 'r+elght and dz;enerat'on or the se`iliniferous tuoul2s in r3*5,
<br /> yU?nee pigs, and raOOit$ were observed. iet3t0(1C1ty in rats a�:d mit_
<br /> dere obser,ied.
<br /> S' r'tOt0Y1C't;/, av^^SS—implant3ti0n mortality, and ?XCr3 "Or'lOnl,
<br /> gtr,.ct'.res in rats dad Tnc° '.Vere OOServed. ?r7-i^lplantaz ion mortalit%,
<br /> . i x.31 r?at:l, and other real afl ec_s in mi ce 'der? oos2r'letl.
<br /> SECTION Y, CHRONIC TOXICITY
<br /> Ap pa :,2 IOR S5, W;Yelan� toss, iazicue, muscle weaknesS, he-uaCh?S,
<br /> dizziness, ner'lOUsneSs, irritability, anemia, irre'lers?ble b100G cnanfiyes,
<br /> and damaga to t;le heart and 1 Iver.
<br /> SECTION 11I. PHYSICAL DATA
<br /> ,dol-cular weicht: 75.12
<br /> 3oiiln Goin: Sat 750 mnt is}: B0- (175 Z))
<br /> ;•?e 41t1a �Oinc (dC 16IJ M�.M 1c 1: ''a.0�C = -1
<br /> Ha) + a0!door Pressure imr ° 74.6
<br /> ;'door lensltl {Air=ll: L.r!
<br /> �. S ecl lc '�r.vll v i azar-1): 0.379
<br /> ?,r Car+t '101dti @3v �71Ume: 100
<br /> E`1a0or3tlon mate (�Utyi acetate =1): 1
<br /> I -0;'J31i?t% In .+lacer: Soiuole
<br /> j,,Ta;rt ZpiUal ity: Miscible with alcohol , chlorororm, ether, carton
<br /> u?sl;.C'��, carnan Ce-rachioride, Glacial acetic acid, acetone, ails.
<br /> 'Dna._rance and Odor: Clear, colorless, rlarrmablz liquid with an oder
<br /> --- ----------a:resnoia-.or-..�-ppm. -------- ------ --._.._- -..----
<br /> l :
<br /> i
<br /> ----- ENVIRdOqiC dA7
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