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Benzene <br /> . ,NSC5-I1Z2 <br /> Page 3 <br /> SECTION IV. LONG-TERM ORGAP11rZ:4 THREAT POTENTIAL <br /> Carcinaaeni�it. <br /> FARC: ited evidence V carcinogenicef.ec.s in animals. Surricfunt <br /> eiicence of carcinogenic elrfec.S in humans. <br /> NTPIPIC I: .'i mcr has repartad Carcinogenic effects. <br /> SLAG has reported carcinogenic effaces. <br /> RTcCS: Carcinogenic by RT--Cs criteria based on cases or leukemia in <br /> Tu—mans and rats. Carcinogenic by RTECS criteria in mica. <br /> �t1u taaeni�ci ty <br /> �4RI {,:;Ynt mutagenic in bacteria, yeast, lnsec.S, or mouse l <br /> 4,. Cei�sym-ph. Chromosomal anomalies in humans, rats, ane mice ,rare observedrvedoma <br /> RTECS: Positive mutagenic responses in bacteria, mica . <br /> and <br /> racoits were observed. DNA damage and chrcmosomai breaks In humans <br /> were observed. <br /> Teratocenicity <br /> TAW: iail abnormalities, Cief't palate, and absence of the lower ,haw <br /> were defects observed in mica. Brain and skeletal defects in rats were <br /> observed. Other studies did rat show teratogenic effects. <br /> RTECS: Abnorma ities of the musculoskeletal System and other effvc« <br /> on the newborn were observed in rats and mica. "s <br /> Reoroductive Effects <br /> 1ARM Alteration of estrus cycles in rats was observed. Increased <br /> tescicu7ar :weight and degeneration of the saminiferous tubules in rats, <br /> guinea pigs, and rabbits were observed. Fetotsxicity. in rats and mica <br /> were observed. <br /> RTECS: ;etotoxicity, Post-implantation mortality, and extra embryonic <br /> zr1C.ur _s in rat; and ,dice were 00sarved. Pre-imalan`a"fan mortality, <br /> Fetal death, and other fetal effects in mice were observed. <br /> SECTION V. CHRORIC TOXICITY <br /> Appetite toss, ,reigns Oss, fatigue, mUSC1e weak;es,, he3dd0eS, <br /> dizziness, narvousiess, irritability, anemia, irreversihie blood changes, <br /> and damage to the heart and liver. <br /> SECTION VI. PHYSICAL. DATA <br /> Moiecular wei ht 78.12 <br /> dal in : oinGf at 760 rum Ha): 8001 (176:F) <br /> ting c,n>: tat DoT Asn ha: 5.S C f42 F) <br /> Vapor Pressure (mm ria dt 71 0C (68'F) ' 74.6 <br /> yaoar Densic : J <br /> z,ev ric'�iic water=I): 0.979 <br /> Percent Yo ati e � olume: 100 <br /> vaooration ata {out acetate yI): 1 <br /> 501uoiiix in Water: n uoToTe <br /> advent �a uoi itv: e-'"ith-- ._al.cohal. ._-chloroform,---ether,-carbon <br /> ---- -�' - -- 4iaUrTiop, caroon cetracilorfde, glacial aretic acid acetone, oils. <br /> An earance and Odor: Clear, cal orIess, fiamnabie� liquid with an odor <br /> rrresno r d or ppm. <br /> : F,NviR0jOgic dATA <br />