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Benzene <br /> SO MSOS-1121 <br /> Page 3 <br /> SECTION IV. LONG—TERM ORGANIEM THREAT POTENTIAL <br /> Carcinogenicity <br /> IARC: Limited evidence of carcinogenic effects in animals . Sufficient <br /> eviaence of carcinogenic effects in humans . <br /> WOW NTP/NCI has reported carcinogenic effects . <br /> 19: _CAG has reported carcinogenic effects. <br /> R TCS: Carcinogenic by RTECs criteria based on cases of leukemia in <br /> humans and rats . Carcinogenic by RTECs criteria in mice. <br /> Mutagenicity <br /> aARi,: Not mutagenic in bacteria, yeast, insects , or mouse lymphoma <br /> ce s. Chromosomal anomalies in humans , rats , ana mice were observed. <br /> RTECS: Positive mutagenic responses in bacteria, mice, rats , and <br /> raooits were observed. DNA damage and chromosomal breaks in humans <br /> were observed. <br /> Teratogenicity <br /> TARC: ?a1i abnormalities, cleft palate, and absence of the lower jaw <br /> were defects observed in mice. Brain and skeletal defects in rats were <br /> observed. Other studies did not show teratogenic effects . <br /> RTECS: Abnormalities of the musculoskeletal system and other effects <br /> on tie newborn were observed in rats and mice . <br /> Reproductive Effects <br /> MRAltera of estrus cycles in rats was observed. increased <br /> tes zi cul ar weight and degeneration of the seminiferous tubules in rats , <br /> guinea pigs , and rabbits were observed. Fetotoxicity in rats and mice <br /> were observed. <br /> RTECS: Fetotoxicity, post—implantation mortality, and extra embryonic <br /> strunures in rats and ,mice were onserved. Pre—implantation mortality, <br /> fetal death , and other fetal effects in mice were observed. <br /> SECTION V. CHRONIC TOXICITY <br /> Appetite 3055 , w eignt loss , fatigue, muscle weakness , headaches , <br /> dizziness , nervousness , irritability, anemia, irreversible blood changes , <br /> and damage to the heart and liver. <br /> SECTION VI. PHYSICAL DATA <br /> Molecular weight: 78.12 <br /> aoiiing Paint (at 760 mm H(3) : 80*C (1760F) <br /> i,1e . ting Point (at /60 mm HiM 5 .5aC (42*F) <br /> Vapor Pressure 1mm Iia) Cat 0'C (63'F)] : 74.6 <br /> Vapor Density (Air=t) : 2.77 <br /> Soecific Gravity water=! ): 0.379 <br /> ercen t Volatile By Volume: 100 <br /> Evaooration Rate utyl acetate Q: 1 <br /> So V uo i i ty in Water: Soluble <br /> Scivent So ups iFT Miscible with alcohol , chloroform, ether , carbon <br /> u1su lride, caroan tetrachloride, facial acetic acid, acetone, oils . <br /> An narance and Odor: Clear , colorless , flammable liquid with an odor <br /> n resnota or 5 ppm. <br /> LNViRO ocic BATA <br />