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Benzene <br /> `(SOS-1121 <br /> page 3 <br /> SECTION IV. LONG—TERM ORGri` EM THREAT POTENTIAL <br /> Carcinogenicity <br /> y. <br /> ISL` Ltmitad evidence of carcinogenic effects in animals. Sufficient <br /> eviaence of carcinogenic effects in humans. <br /> NTP/NCI: NT?/NCI has reported carcinogenic effects. <br /> has reported carcinogenic effects. <br /> UT-CS: Carcinogenic by RTcCs criteria based on cases of leukemia in <br /> humans and rats. Carcinogenic by RTECS criteria in mice. <br /> Mu taaen i c i t- <br /> �: Not mutagenic in bacteria, yeast, insects, or mouse lymphoma <br /> ceTTS. Chromosomal anomalies in humans, rats, and mice were observed. <br /> RTECS: Positive mutagenic responses in bacteria, mice, rats, and <br /> raablts were observed. DNA damage and chromosomal breaks in humans <br /> were observed. <br /> " Teratoaenicit <br /> Tail abnormalities, cleft palate, and absence of the lower ,haw <br /> ;ere defects observed in nice. Brain and skeletal defects in rats were <br /> If observed. Other studies did not show teratogenic affects. <br /> RTECS: Abnormalities of the musculoskeletal system and other effects <br /> an the newborn were observed in rats and mice. <br /> Reproductive Effects <br /> fteratton of estrus cycles in rats was observed. Increased <br /> testicular :-night and degeneration of the seminiferous tubules in rats, <br /> guinea pigs, and rabbits were observed. Fetotoxicity in rats and mice <br /> were observed. <br /> RTECS: Fetotoxicity, post—implantation mortality, and extra eniryonic <br /> structures in rats and mice were observed. Pre—implantation mortality, <br /> fetal death, and other fetal effects in mice were observed. <br /> SECTION V. CHRONIC TOXICITY <br /> Appetite ,ass, weignt loss, fatigue, muscle weakness, headaches, <br /> dizziness, nervousness, irritability, anemia, irreversible blood changes, <br /> and damage to the heart and liver. <br /> SECTION VI. PHYSICAL. DATA <br /> Motecilar weight. 78.12 <br /> oo �n oint at 760 mm $0'C (I76'F) <br /> ;4e.t1nc atnt at 16U mm Nal: 5.5;C (42'F) <br /> aper ressure mm xa1 ac OAC (63'F)]: 74.6 <br /> Vaoor Liens a Atr;. is i <br /> oeciricT vit+ (water-1): 0.875 <br /> ercent volatile o ume: 100 <br /> vaoorarionRa-.e (oucylacetate =I): 1 <br /> S01u0t 11t in water: o uo e <br /> 3- o uo�: Miscible with alcohol , chloroform, ether, carbon <br /> u1suirtae, taroon tetrachloride, glacial acetic acid, acetone, oils. <br /> ,noaarance and Odor: Clear, colorless, flaamaole. liquid with an odor <br /> Frresna a or a ppm. <br /> ENVIRO10ric BATA <br />