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Chemwatch:4650.10 Page 10 of 15 Issue Date:11/16/2017 Version No:6.1.1.1 Phosphate Test Solution#1 Print Date:06121/2019 increased risk of laryngeal cancer being seen with chronic exposures.Repeated minor exposures to mists can cause erosion of teeth and inflammation of the upper respiratory tract leading to chronic bronchitis.Repeated skin contact with dilute solutions may produce dermatitis.Lungs of sulfuric acid plant workers appear to be less affected than the lungs of workers exposed to"dust".There is evidence that corrosion of tooth enamel occurs at 1 mg/m3 but that acclimated workers could tolerate three to four times that level.Forming room workers in a battery factory exposed to 3 to 16 mg/m3 sulfuric acid mist concentrations exhibited the most serious signs of erosion whilst charging room workers,exposed to 0.08 to 2.5 mg/m3 were affected to a lesser degree.Workers chronically exposed to sulfuric acid mists may show various skin lesions,tracheobronchitis,stomatitis,conjunctivitis and gastritis. Phosphate Test Solution TOXICITY IRRITATION #1 Not Available Not Available TOXICITY IRRITATION SULFURIC ACID 40% Inhalation(guinea pig)LC50:0.036 mg/I/8H121 Eye(rabbit):1.38 mg SEVERE Oral(rat)LD50:2140 mg/kg[21 Eye(rabbit):5 mg/30sec SEVERE TOXICITY IRRITATION ammonium dermal(rat)LD50:>2000 mg/kgI1I Eye:no adverse effect observed(not irritating)['] heptamolybdate Oral(rat)LD50:>2000 mg/kg111 Skin:no adverse effect observed(not irritating)['] Legend: 1.Value obtained from Europe ECHA Registered Substances Acute toxicity 2.*Value obtained from manufacturer's SDS. Unless otherwise specified data extracted from RTECS-Register of Toxic Effect of chemical Substances WARNING:For inhalation exposure ONLY:This substance has been classified by the IARC as Group 1:CARCINOGENIC SULFURIC ACID 40% TO HUMANS Occupational exposures to strong inorganic acid mists of sulfuric acid: The following information refers to contact allergens as a group and may not be specific to this product. Contact allergies quickly manifest themselves as contact eczema,more rarely as urticaria or Quincke's oedema.The pathogenesis of contact eczema involves a cell-mediated(T lymphocytes)immune reaction of the delayed type.Other AMMONIUM allergic skin reactions,e.g.contact urticaria,involve antibody-mediated immune reactions.The significance of the contact HEPTAMOLYBDATE allergen is not simply determined by its sensitisation potential:the distribution of the substance and the opportunities for contact with it are equally important.A weakly sensitising substance which is widely distributed can be a more important allergen than one with stronger sensitising potential with which few individuals come into contact.From a clinical point of view,substances are noteworthy if they produce an allergic test reaction in more than 1%of the persons tested. No significant acute toxicological data identified in literature search. Asthma-like symptoms may continue for months or even years after exposure to the material ceases.This may be due to a non-allergenic condition known as reactive airways dysfunction syndrome(RADS)which can occur following exposure to high levels of highly irritating compound.Key criteria for the diagnosis of RADS include the absence of preceding SULFURIC ACID 40%g, respiratory disease,in a non-atopic individual,with abrupt onset of persistent asthma-like symptoms within minutes to AMMONIUM hours of a documented exposure to the irritant.A reversible airflow pattern,on spirometry,with the presence of moderate HEPTAMOLYBDATE to severe bronchial hyperreactivity on methacholine challenge testing and the lack of minimal lymphocytic inflammation, without eosinophilia,have also been included in the criteria for diagnosis of RADS.RADS(or asthma)following an irritating inhalation is an infrequent disorder with rates related to the concentration of and duration of exposure to the irritating substance.Industrial bronchitis,on the other hand,is a disorder that occurs as result of exposure due to high concentrations of irritating substance(often particulate in nature)and is completely reversible after exposure ceases.The disorder is characterised by dyspnea,cough and mucus production. Acute Toxicity X Carcinogenicity X Skin Irritation/Corrosion 01 Reproductivity X Serious Eye 01 STOT-Single Exposure X Damage/Irritation Respiratory or Skin 01 STOT-Repeated r sensitisation Exposure Mutagenicity X Aspiration Hazard X Legend: X —Data either not available or does not fill the criteria for classification 9,I—Data available to make classification SECTION 12 ECOLOGICAL INFORMATION Toxicity Continued...