COMPLIANCE INFO_2020 - Laserfiche WebLink

Home Browse Search

Chemwatch:4650.17 Page 7 of 12 Issue Date:06/27/2017 Version No:6.1.1.1 Phosphate Test Solution#2 Print Date:06/21/2019 Unstable in the presence of incompatible materials. Chemical stability Product is considered stable. Hazardous polymerisation will not occur. Possibility of hazardous See section 7 reactions Conditions to avoid See section 7 Incompatible materials See section 7 Hazardous See section 5 decomposition products SECTION 11 TOXICOLOGICAL INFORMATION Information on toxicological effects The material is not thought to produce adverse health effects or irritation of the respiratory tract(as classified by EC Directives using animal models).Nevertheless,good hygiene practice requires that exposure be kept to a minimum and Inhaled that suitable control measures be used in an occupational setting. Not normally a hazard due to non-volatile nature of product The material has NOT been classified by EC Directives or other classification systems as"harmful by ingestion".This is because of the lack of corroborating animal or human evidence.The material may still be damaging to the health of the individual,following ingestion,especially where pre-existing organ(e.g liver,kidney)damage is evident.Present Ingestion definitions of harmful or toxic substances are generally based on doses producing mortality rather than those producing morbidity(disease,ill-health).Gastrointestinal tract discomfort may produce nausea and vomiting.In an occupational setting however,ingestion of insignificant quantities is not thought to be cause for concern. The material may produce mild skin irritation;limited evidence or practical experience suggests,that the material either: produces mild inflammation of the skin in a substantial number of individuals following direct contact,and/or produces significant,but mild,inflammation when applied to the healthy intact skin of animals(for up to four hours), such inflammation being present twenty-four hours or more after the end of the exposure period. Skin Contact Skin irritation may also be present after prolonged or repeated exposure;this may result in a form of contact dermatitis (non allergic).The dermatitis is often characterised by skin redness(erythema)and swelling(oedema)which may progress to blistering(vesiculation),scaling and thickening of the epidermis.At the microscopic level there may be intercellular oedema of the spongy layer of the skin(spongiosis)and intracellular oedema of the epidermis. Entry into the blood-stream through,for example,cuts,abrasions,puncture wounds or lesions,may produce systemic injury with harmful effects.Examine the skin prior to the use of the material and ensure that any external damage is suitably protected. Limited evidence or practical experience suggests,that the material may cause eye irritation in a substantial number of individuals.Repeated or prolonged eye contact may cause inflammation characterised by temporary redness(similar to Eye windburn)of the conjunctiva(conjunctivitis);temporary impairment of vision and/or other transient eye damage/ulceration may occur. Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects involving organs or biochemical systems. Glyceryl triesters(triglycerides),following ingestion,are metabolised to monoglycerides,free fatty acids and glycerol,all of which are absorbed in the intestinal mucosa and undergo further metabolism.Medium chain triglycerides (C8-C10) appear to have relatively rapid metabolism and elimination from blood and tissues compared to long chain triglycerides (C16-C18).Little or no acute,subchronic or chronic oral toxicity was seen in animal studies unless levels approached a significant percentage of calorific intake.Subcutaneous injections of tricaprylin in rats over a five-week period caused granulomatous reaction characterised by oil deposits surrounded by macrophages.Diets containing substantial levels of tributyrin produced gastric lesions in rats fed for 3-35 weeks;the irritative effect of the substance was thought to be the cause of tissue damage. Dermal application was not associated with significant irritation in rabbit skin;ocular exposures were,at most,mildly irritating to rabbit eyes.No evidence of sensitisation or photosensitisation was seen in a guinea pig maximisation test. Most of the genotoxicity test systems were negative.Tricaprylin,trioctanoin and triolein have been used,historically,as vehicles in carcinogenicity testing of other chemicals.In one study,subcutaneous injection of tricaprylin,in newborn Chronic mice,produced more tumours in lymphoid tissue than were seen in untreated animals whereas,in another study, subcutaneous or intraperitoneal injection in 4-to 6-week old female mice produced no tumours.Trioctanoin injected subcutaneously in hamster produced no tumours;when injected intraperitoneally in pregnant rats there was an increase in mammary tumours among the off-spring but similar studies in pregnant hamsters and rabbits showed no tumours in the off-spring. The National Toxicological Program conducted a 2-year study in rats given tricaprylin by gavage.The treatment was associated with a statistically significant dose-related increase in pancreatic acinar cell hyperplasia and adenoma but there were no acinar carcinomas. Tricaprylin is not teratogenic to mice or rats but some reproductive effects were seen in rabbits.A low level of foetal eye abnormalities and a small percentage of abnormal sperm were reported in mice injected with trioctanoin. Trioctanoin was also used as a vehicle control in a sperm abnormality test.Ten male control mice received an intraperitoneal injection of 0.25 ml trioctanoin 0.05 g/kg of benz[a]pyrene(known reproductive toxicant and mutagen)daily for 5 days and sperm from caudae epididymides analysed.Based on these studies there is no sufficient evidence to classify the Continued...