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Chemwatch:4650.13 Page 14 of 18 Issue Date:11/12/2018 Version No:7.1.1.1 API Pond Ammonia Test Solution#1 Print Date:06/21/2019 ethylene oxide and water or ethylene glycol(or other ethylene glycol oligomers),as catalyzed by acidic or basic catalysts. To produce PEO or high-molecular weight PEGs,synthesis is performed by suspension polymerization.It is necessary to hold the growing polymer chain in solution during the course of the poly-condensation process.The reaction is catalyzed by magnesium-,aluminum-,or calcium-organoelement compounds.To prevent coagulation of polymer chains in the solution,chelating additives such as dimethylglyoxime are used Safety Evaluation of Polyethyene Glycol(PEG)Compounds for Cosmetic Use:Toxicol Res 2015;31:105-136 The Korean Society of Toxicology http://dol.org/l 0.5487/TR.2015.31.2.105 The material may be irritating to the eye,with prolonged contact causing inflammation.Repeated or prolonged exposure to irritants may produce conjunctivitis. The material may cause skin irritation after prolonged or repeated exposure and may produce a contact dermatitis (nonallergic).This form of dermatitis is often characterised by skin redness(erythema)and swelling epidermis. Histologically there may be intercellular oedema of the spongy layer(spongiosis)and intracellular oedema of the epidermis. for molecular weights(200-8000)*Oral(rat)LD50:31000->50000 mg/kg Oral(mice)LD50:38000->50000 mg/kg Oral (g.pig)LD50:17000->50000 mg/kg Oral(rabbit)LD50:14000->50000 mg/kg*AIHA WEEL Guides Intraperitoneal(mice) LD50:3100-12900 mg/kg Asthma-like symptoms may continue for months or even years after exposure to the material ceases.This may be due to a non-allergenic condition known as reactive airways dysfunction syndrome(RADS)which can occur following exposure to high levels of highly irritating compound.Key criteria for the diagnosis of RADS include the absence of preceding respiratory disease,in a non-atopic individual,with abrupt onset of persistent asthma-like symptoms within minutes to hours of a documented exposure to the irritant.A reversible airflow pattern,on spirometry,with the presence of moderate SODIUM SALICYLATE-USP to severe bronchial hyperreactivity on methacholine challenge testing and the lack of minimal lymphocytic inflammation, without eosinophilia,have also been included in the criteria for diagnosis of RADS.RADS(or asthma)following an irritating inhalation is an infrequent disorder with rates related to the concentration of and duration of exposure to the irritating substance.Industrial bronchitis,on the other hand,is a disorder that occurs as result of exposure due to high concentrations of irritating substance(often particulate in nature)and is completely reversible after exposure ceases.The disorder is characterised by dyspnea,cough and mucus production. I Exposure to the material for prolonged periods may cause physical defects in the developing embryo(teratogenesis). Acute Toxicity tr Carcinogenicity X Skin Irritation/Corrosion X Reproductivity X Serious Eye ✓ STOT-Single Exposure X Damage/irritation Respiratory or Skin X STOT-Repeated X sensitisation Exposure Mutagenicity X Aspiration Hazard X Legend: X —Data either not available or does not fill the criteria for classification %e—Data available to make classification SECTION 12 ECOLOGICAL INFORMATION Toxicity ENDPOINT TEST DURATION(HR) SPECIES VALUE SOURCE API Pond Ammonia Test Solution#1 Not Not Available Not Available Not Not Available Available Available ENDPOINT TEST DURATION(HR) SPECIES VALUE SOURCE polyethylene glycol LC50 96 Fish 20-mg/L 2 EC50 72 Algae or other aquatic plants 15.915mg/L 2 ENDPOINT TEST DURATION(HR) SPECIES VALUE SOURCE SOD NITROPRUSSIDE SOLUTION Not Not Available Not Available Not Not Available Available Available ENDPOINT TEST DURATION(HR) SPECIES ; VALUE SOURCE LC50 96 Fish 1-370mg/L 2 SODIUM SALICYLATE-USP EC50 72 Algae or other aquatic plants 48.29mg/L 2 ECO 24 Crustacea 80mg/L 4 NOEC 504 Crustacea 4.126mg/L 2 Legend: Extracted from 1.IUCLID Toxicity Data 2.Europe ECHA Registered Substances-Ecotoxicological Information-Aquatic Toxicity 3.EPIWIN Suite V3.12(QSAR)-Aquatic Toxicity Data(Estimated)4.US EPA,Ecotox database-Aquatic Toxicity Continued...