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.NO.318 Xyienc(Mixed Isomers) 9/92
<br /> Section 6. Health Hazard Data continuedthe human
<br /> m
<br /> t-seFukaris}'µ'as reported in arse:lotion with workplace exposure to xviene hap due.t0 effects on liver rrctabolism.Xylene crosses NS,
<br /> placenta,but docs not appear to be teratogenic under conditions tested w date. Medical Conditions gravated by Long-Term Exposure:
<br /> respiratory,eye,skin,gastrointestinal(GI),liver and kidney disorders. Target Organs:CNS,eves,Gl tnc�lives,kidneys,and skin. Primary
<br /> t),eye contact,ingestion. Acute Effects:Inhalation of high xylene concentrations may cause
<br /> Entry Routes:Inhalation•skin absorption(sligh
<br /> Entryand throat irritation;respiratory tract irritation leading to pulmonary edema(fluid in
<br /> dizziness:nausea,vomiting,and abdominal path:eve.nose.
<br /> lung):drowsiness;and unconsciousness.Direct eve contact can result in conjunctivitis and corneal burns.Ingestion may cause a burning d defion
<br /> in the oropharynx and stomach and transient CNS depression. Chronic Effects:Repeated or prolon skin e�e t me
<br /> mag u drying central
<br /> ting of the skin leading to dermatitis.Repeated eye exposure to high vapor concentrations mayreversibleY
<br /> neuropathy,and liver damage.Other symptoms of chronic exposure include headache,fatigue,irritability,chronic bronchitis,and GI disturbances
<br /> such as nausea,loss of appetite,,and gas• or es tightly shut Gently lift eyelids
<br /> FIRST AID Emergency persoriite!should protect against expost+re.Eyes:Do not allow to an emergency
<br /> meed cal facility.Consult a physician
<br /> and flush immediately and continuously with floodingamounts of water until transported 8 Y
<br /> immediate!}'.Skin:QuicAly remove contaminated clothing.Rinse with flooding amounts of water for at least 15 mint.Wash exposed arca with soap
<br /> and water.For reddened or blistered sign, POs
<br /> consult a physician.Carefully dispose of contaminated clothingas tdmaesin artier Never giveation:
<br /> Remove exposed person to fresh air and support breathing as needed:Monitor exposed person for respiratory >y !
<br /> anything by mouth tea an unconscious or convulsing person.Contact a poison control center and unless otherwise advised,do not induce vomiting.If
<br /> spontaneous voliq
<br /> miting should occur:keep exposed person's head below the hips to prey aspi
<br /> ration
<br /> ha S Note tuid o Physicianslene into : acid
<br /> Aspiration of a few millimeters of amylene can cause chemical pneumonitis,pulmonary
<br /> ederna,andor the ether glucuronide of ortho-toluic acid may be useful in diagnosis of meta•,para. and Ortho-xylene exposure,respectively.Consider gastric
<br /> lavage,if a large quantity of xylene was ingested.Proceed gastric lavage with proieetion of the airway from aspiration:consider endotracheal
<br /> inwbatioh with inflated cuff. :
<br /> Section 7 ..:SOil l, Leal:;and':Disposal P.racedures.'. ?.......
<br /> Spi111l.eak:Notify safety persdnneL evacuate all unnecessary personnel,remove all Beat and ignition sources.and ventilate spill area.Cleanup
<br /> personnel should protect against vapor inhalation and skin or eye contact.If feasible and without undue risk+stop leak.Use appropriate foam to
<br /> blanket release and suppress vapors.Water spray may.reduce vapor,but does not prevent ignition in closed spaces.For smfor litiff all spills,absorb on paper
<br /> and evaporatein appropriate exhaust!rood or absorb with sand or some non-combustible se absorbent suchass se`pec or drains.
<br /> � Orland,dike to con limn or
<br /> large spills dike far ahead of liquid to contain.Do not allow xy�pent enter
<br /> confvapor ined
<br /> material with pumps or vacuum equipment.On
<br /> divert to impermeable holding area-Apply water spray
<br /> to water,contain material with natural barritus.booms,or weirs:apply universal gelllm agent:and use suction hoses to remove spilled material.
<br /> Report any release in excess of 1000 lb. Follow applicable OSHA regulations(29 CFR 1910.120). Environmental Transport:little bioconcen-
<br /> tration is expected.Biological oxygen demand 5(after 5 days at 20'C):0.54(no stated isomer).Ecotoxicity values:LDsa Goldfish,13 mg/iJ24 hr.
<br /> conditions of bioassay not specified,no specific isomer. Environmental Degradation:In the atmosphere,xylenes degrade by reacting with
<br /> photochempcally produced hydroxyl radicals with a half-life ranging from 1-1.7 hr.in the summer to 10-18 hr in winter or a typical loss of b7-86'10
<br /> per day-Xylenes arc resistant to hydrolysis.Soil Absorption Mobility:Xylenes have low m moderate adsorption to soil and when spilled on land,
<br /> will volatilize and leach into groundwater,Disposal:Asa hydrocarbon,xvlene is a good candidate for controlled incineration.Contact your supplier
<br /> or a licensed contractor for detailed recommendations.Follow applicable Federal O A Dnlocal ation tions.
<br /> EPA Designations ]fisted as an Air Contaminant(29 CFR 1910.1000,Table Z-1-A)
<br /> SARA Extremely Hazardous Substance(40 CFR 355):Not listed
<br /> Listed as a SARA Toxic Chemical(40 CFR 372.65)
<br /> Listed as a RCRA Hazardous Waste(40 CFR 261.33):No:U239,F003(spent solvent) I lb(454 kg)['per Clean Water Act
<br /> Listed as a CERCLA Hazardous Substance*(40 CFR 302.4):Final Reportable Quantity(RQ),
<br /> Sec.311(b)(4);per RCRA,Sec.300I)
<br /> Section 8':<Sp:eciai'Rrotection Data
<br /> Goggles:Wear protective eyeglasses or Chemical safety goggles Per OSHA eye and face-protection regulations(29 CFR 1910.133) Because
<br /> contact]ens use in industry is controversial,establish your own policy.ResWir selection and use.
<br /> car .a MSeeprofessionalro�ed respirator. ncentrations 1000
<br /> Follow OSHA respirator regulations(29 CFA 1910.134)and,if necessary, respirator with organic vapor cartridges;any
<br /> ppm,use any chemical cartridge respirator with organic vapor cartridges;any powered,air-purifying resp ills,reactor vessels.or
<br /> supplied-air respirator,or any self-contained breathing apparatus.For emergency or nataoutine operations(cleaning heres.If
<br /> _are
<br /> storage tanks).weer an SCBA.Warning!Air-purifying respirators ond gau�e s tnor o prevent all skin corotect workers i ntact.With b Breakthrough times S r.consider
<br /> ed,
<br /> Other:Wear chemically protective gloves,boots,
<br /> aprons,
<br /> polyvinyl alcohol and fluorocarbon rubber(Viton)as materials for PPE.Ventilation:Provide general and local exhaust ventilation systems sA
<br /> maintain airborne concentrations below the OSHA PELs(Sec.2).Local exhaust ventilation is preferred because it prevents
<br /> stations,saftam nanety'sPers n
<br /> i ito the work area by controlling it at its source. Safety Stations:Make available in the work area emergency et'
<br /> drench showers and washing factltues.Contaminated Equipment:Separate contaminated work clothes from street clothes.Launder contami-
<br /> named work clothing bdore.wearing.Remove this material from your shoes and clean PPE•smokinCommg,usingethe tver oet,or aink.pplying cosmetics areas.e in work
<br /> Practice good personal hygiene after using this material.especially before eating.drinking. S•
<br /> Section 9. Special Precautions and Comments �j
<br /> Storage R d uinstsourc11 S tes.During transferring oghLly closed,pmtions•elrctricaally g'r'ound aers in a mend bond metal contplace,Ewaainers. Engif from
<br /> Controls:To reduces
<br /> and'neat anignition
<br /> potential health hazards,fire sufficient dilution or local exhaust ventilation w control airborne contaminants and to maintain concentrations at e
<br /> equipmem transfer xylene in enclosed systems,avoid processes associated with open evaporating
<br /> lowest practical level.Use hermetics]]}'scaled
<br /> surfaces,and provide sources of gas release with enclosures and local exhaust ventilation.Use Class I Group D electrical equipment Administra
<br /> tive Controls:Establish air and biological monitoring program and evaluate regularly.Consider preplacement and periodic medical examinations
<br /> including a complete blood count.a routine urinalysis,and liver function tests.Consider hematologic studies if there is any significant contamination
<br /> of the solvent with'bcnzcnc.If feasible,consider the replacement of xylene by less toxic solvents such as petrol(motor fuel)or white sPiri�Before
<br /> carrying out maintenance and repair wort:.steam and flush all equipment to remove any xylene residues. +...
<br /> Transportation Data(49 CFR 172.101) K° Vessel Stowage Re utrements
<br /> Quantity Limitations i
<br /> DOT Shipping Tame: XvIenes -Packaging ns: 173.150 rte Q Passer .erAircraft.or Railcar:5L a)Vessel Stowage:
<br /> DOT Hazard Class:3 a) Exceptions: 173.154 .b)Cargo Aircraft Only:60L b)Other.—
<br /> ID No.: UN1307 b)Nonbull Packaging: 1'13.202'
<br /> DOT f asking Group:D c)Bulk Packaging: 173.242 '- 5
<br /> DOT Label:Flammable Liouid
<br /> Special Provisions(172.703):T1
<br /> hf5D5 CoUecnlon Referenccsi 26,73,S9,100,101,103,124.12b,127.132.133,136,139,140, 148.149_,153,159.163,164,167,171.174,175,]S0.
<br /> Prepared by:MJ Wurth,BS:Industrial Hy¢iene Review:PA Roy,MPH,CII!:Medical Review:µ'Silverman,Mn
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