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285-21 2.1 VOC Primer NLR 285212 0 9 Page 5 SECTION 5 - HEALTH EFFECTS (cont) classified crystalline silica in Group 1 (those agents with evidence of carcinogenicity to humans) and National Toxicology Program (NTP) has included it in its Annual Report on Carcinogens. Prolonged or repeated exposure to talc can result in a form of pulmo- nary fibrosis (talc pneumoconiosis) , possibly due to asbestos content. In a National Toxicology Program (NTP) inhalation study, talc exhibited some evidence of carcinogenicity in male rats, clear evidence in female rats and no evidence in mice. It is thought that the effects, which were reported at the high dose, were due to overburdening of the lungs. In a National Cancer Institute (NCI) feeding study, titanium dioxide was not carcinogenic to rats or mice at maximum tolerated doses. In another study, TiO2 caused fibrosis and lung cancer in rats exposed to 250 mg/m3 by inhalation. However, no effects were seen at lower airborne concentrations. Repeated inhalation exposures to 2-heptanone (methyl amyl ketone) have been known to produce neurological effects in experimental animals at 1000 ppm. Repeated oral exposures in rats have been known to produce liver and kidney effects at 500 mg/kg/day. First Aid Procedures - Skin: Wash affected areas with soap and water. Remove and launder contaminated clothing before reuse. If irritation develops, get medical attention. First Aid Procedures - Eyes: Flush with copious amounts of water for at least 15 minutes. Hold eyelids open to facilitate rinsing. Seek medical assistance immediately. First Aid Procedures - Ingestion: If swallowed, dilute with water. DO NOT INDUCE VOMITING DUE TO ASPIRATION HAZARD. Never give fluids or induce vomiting if the victim is unconscious or having convulsions. Get immediate medical attention_ FirstAid Procedures - Inhalation: Remove to fresh air. Restore breathing. Keep warm and quiet. Notify a physician. First Aid Procedures - Notes to Physicians: Contact the local Poison Control Center or call BASF Emergency Response at 1-800-832-HELP (4357) . First Aid Procedures - Aggravated Medical Conditions: No data is available which addresses medical conditions that are generally recognized as being aggravated by exposure to this product. Please refer to the effects of overexposure section for effects (if any) observed in animals. First Aid Procedures - Special Precautions: None SECTION 6 - REACTIVITY DATA Stability Data: Stable Incompatability: Strong acids, alkalies, and oxidizers.