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AR EMA SAFETY DATA SHEET <br /> . .........._ <br /> RILSAN® 5956 GREY RDP 15-10 ES <br /> Carcinogeniciri <br /> Chronic dietary administration to rat and mouse/signs: No increase in tumor incidence was reported. <br /> Chronic inhalation administration to rat/affected organ(s): lung /signs: Increase in tumor incidence <br /> was reported. <br /> Classified by the International Agency for Research on Cancer as: Group 213: Possibly carcinogenic to humans. <br /> Genotoxicity <br /> Assessment in Vitro: <br /> No genetic changes were observed in laboratory tests using: bacteria,animal cells,yeast <br /> Genotoxiciri <br /> Assessment in Vivo: <br /> No genetic changes were observed in laboratory tests using: mice, rats <br /> Other information <br /> The information presented is from representative materials in this chemical class. The results may vary <br /> depending on the test substance. <br /> Human experience <br /> Skin contact: <br /> Skin: No skin allergy was observed. (studied using human volunteers) <br /> Data for C.I. Pigment Blue 28(1345-16-0) <br /> Acute toxicity <br /> Oral: <br /> No deaths occurred.(rat)LD50>10,000 mg/kg. <br /> Carcinoaeniciri <br /> Long term implantation administration to rodent/affected organ(s):site of contact /signs: Increased <br /> incidence of tumors was reported. <br /> Chronic inhalation administration to animals/affected organ(s):lung /signs: Increased incidence of <br /> tumors was reported. <br /> Classified by the International Agency for Research on Cancer as:Group 2B: Possibly carcinogenic to humans. <br /> (cobalt compounds) <br /> Genotoxiclty <br /> Assessment in Vitro: <br /> Both positive and negative responses for genetic changes were observed In laboratory tests on similar <br /> materials using: bacteria,animal cells <br /> Genotoxicity <br /> Assessment in Vivo: <br /> Both positive and negative responses for genetic changes were observed in laboratory tests using: rats, <br /> mice, (data for similar material) <br /> Developmental toxicity <br /> Product code:A09469 Version 1.0 Issued on: 05/15/2015 Page: 11 /16 <br /> Quick-FDS(17303-32698-27051-0167981-2015-05-16-09:04:58 <br />