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I I j , j 1 6)0 010 DELTA BLOOD BANK BIOSAFETY Hepatitis B Virus Vaccination Program The 1985 CDC guideline recommends HBV vaccination for personnel considered at risk for exposure to the virus in their occupational activities. Delta Blood Bank offers the series of HBV inoculations at no charge to employees at risk. Who is at risk? In the blood bank, the potential for occupational exposure begins with the initial finger stick of the donor and con- tinues until contaminated units are identified and des- troyed. Employees engaged in the collection' -and -processing of blood are at risk for exposure. Housekeeping and maintenance workers, particularly those in patient care and laboratory areas are at risk. Others at risk of exposure include employees who assist in donor collection by sealing tubing, those who handle materials contaminated by blood, and anyone dealing with infectious waste. Pre -exposure vaccination is recommended for persons at risk of exposure who are or may be unprotected. Persons ( with anti -HBs titers of at least 10 mIU/ml are considered to 1. be protected against hepatitis B. After exposure to hepatitis B virus, HBV vaccine is also recommended for unprotected individuals as part of the therapy to prevent infection. What is hepatitis B virus vaccine? Delta Blood Bank provides immunization with a recombinant HBV vaccine called Engerix-B, manufactured by SmithKline Biologicals. Engerix-B is a noninfectious recombinant DNA hepatitis B vaccine. It contains purified surface antigen of the virus obtained by culturing genetically engineered Saccharomyces cereviseae cells which carry the surface antigen gene of the hepatitis B virus. The surface antigen expressed in these yeast cells is purified further, resulting in a product that contains no more than 5% yeast protein. No substances of human origin are used in vaccine manu- facture. BIOSAFETY - HBVVAC - 0491 - PAGE 1