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0 0 <br /> to diesel exhaust particulates, a complex mixture of combustion products of diesel fuel, is <br /> reasonably anticipated to be a human carcinogen. In addition, NIOSH has identified complete <br /> diesel exhaust as a potential carcinogen. <br /> Middle Distillates, Petroleum: <br /> The products represented by this MSDS contain a mixture of petroleum hydrocarbons commonly <br /> referred to as"middle distillates". Laboratory data have associated some middle distillates with <br /> skin cancer when the material is applied repeatedly over the lifetime of the test animal. Middle <br /> distillates similar to the products represented by this MSDS have been associated with liver and <br /> kidney damage in sub-chronic(90 day) inhalation studies of male rats. The relevance of these <br /> findings to human health is unclear. <br /> Hydrodesulfurized Middle Distillate, Petroleum: <br /> INHALATION LC50,Acute: 4.6 to 7.64 mg/L for four hours[Rat]—Dyspnea, nasal discharge, <br /> alopecia and excessive salivation. <br /> ORAL LD50,Acute: >500 g/kg [Rat Screening Level]—Diarrhea, hyperactivity, ptosis and <br /> somnolence. <br /> DERMAL LD50,Acute: >2,000 mg/kg [Rabbit Screening Level] <br /> BUEHLER DERMAL,Acute: Non-sensitizing [Guinea Pig] <br /> 14-DAY DERMAL, Subchronic: 0.05 ml/kg applied 3x/week[Mouse, Human Skin grafted to <br /> Athymic nude mice]—Irritation and epidermal hyperplasia <br /> 62-WEEK DERMAL, Chronic: 0.05 ml/kg applied 3x/week[Mouse]—Extreme Skin Irritation, <br /> moderate increase in contact-point skin tumors. <br /> Trimethylbenzenes,all isomers <br /> The TCLo for humans is 10 ppm, with somnolence and respiratory tract irritation noted. In <br /> inhalation studies with rats, four of ten animals died after exposures of 2400 ppm for 24 hours. <br /> An oral dose of 5 ml/kg resulted in death in one of ten rats. Minimum lethal intraperitoneal doses <br /> were 1.5 to 2.0 ml/kg in rats and 1.13 to 12 ml/kg in guinea pigs. Levels of total hydrocarbon <br /> vapors present in the breathing atmosphere of these workers ranged from 10 to 60 ppm. <br /> Mesitylene(1,3,5 Trimethylbenzene) inhalation at concentrations of 1.5, 3.0 and 6.0 mg/L for six <br /> hours was associated with dose-related changes in white blood cell counts in rats. No significant <br /> effects on the complete blood count were noted with six hours per day exposure for five weeks, <br /> but elevations of alkaline phosphatase and SGOT were observed. Central nervous system <br /> depression and ataxia were noted in rats exposed to 5,100 to 9,180 ppm for two hours. <br /> Naphthalene <br /> Naphthalene is a potential irritant to eyes, skin and lungs. Ingestion of naphthalene has been <br /> associated with severe red blood cell and liver damage leading to death. Following prolonged or <br /> repeated exposures, naphthalene has been shown to cause cataracts, optical neuritis, hemolytic <br /> and aplastic anemia,jaundice and possibly neurotoxicity. In animal studies, naphthalene caused <br /> fetal effects and decreased spleen weights in pregnant female mice. In an NTP sponsored study, <br /> naphthalene produced a dose related increase in tumors at the 30 and 60 ppm exposure level in <br /> both male and female rats. Higher incidences of respiratory epithellal adenomas, olfactory <br /> epithellal neuroblastomas, and non-neoplastic lesions of the nose were observed as compared to <br /> controls. Cytogenic studies with Chinese hamster ovary cells have demonstrated sister <br /> chromatid exchanges and chromosomal aberrations. The relevance of these studies to human <br /> health is unclear. <br /> Biphenyl (Diphenyl): <br /> 7 <br />